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Department:
Whitney Laboratories
Concentrations:
Accepting Students
No
Last Updated
5/24/2016 12:39:53 PM
Research Description
Chemical senses, sensory physiology, invertebrate neurobiology.
Department:
Otolaryngology
Concentrations:
Accepting Students
No
Last Updated
5/31/2016 8:00:52 AM
Research Description
Hearing loss and facial paralysis: prevention and treatment
Department:
Ophthalmology
Concentrations:
Accepting Students
No
Last Updated
6/29/2016
Research Description
Research is focused on mechanisms of inherited retinal degeneration and neuroprotection. His most recent studies have shown the important contribution of endogenously expressed cytokines such as leukemia inhibitory factor (LIF)
Department:
Neuroscience
Concentrations:
Accepting Students
Yes
Last Updated
7/29/2016
Research Description
Department:
Neuroscience
Concentrations:
Accepting Students
No
Last Updated
6/1/2016 12:34:28 PM
Research Description
Molecular mechanisms of age related cognitive decline
Department:
Neuroscience
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
Develop technology and application of magnetic resource imaging and spectroscopy.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Last Updated
6/1/2016 11:01:32 AM
Research Description
The focus of the lab is on the molecular basis of pathogenesis of the herpesviruses and the application of these concepts and control of latent gene expression. Specifically we have recently been investigating the role of HSV non-coding RNAs on the regula
Department:
Physiological Sciences
Concentrations:
Accepting Students
No
Last Updated
6/29/2016
Research Description
A variety of neuromuscular diseases result in impaired cough (dystussia) and/or impaired swallow function (dysphagia). Cough and swallows are controlled by complex brainstem networks which, until recently, have been studied in isolation. However, in neuro
Department:
Neuroscience
Concentrations:
Accepting Students
No
Last Updated
5/31/2016 12:51:04 PM
Research Description
My lab uses transgenic & knockout mouse models, and cell models, to determine molecular mechanisms by which mutations in specific genes cause familial neurodegenerative diseases - primarily Alzheimer's disease and amyotrophic lateral sclerosis.
Department:
Physiological Sciences
Concentrations:
Accepting Students
No
Last Updated
6/1/2015 1:58:03 PM
Research Description
Understanding the molecular-physiological-through-behavioral neurobiology of motor, sensory and cognitive plasticity following pharmacotherapy and neurorehabilitation using preclinical (rodent) models of neurotrauma (spinal cord, traumatic brain injuries, and stoke), and neurodegenerative/neuro-autoimmune diseases (e.g., MS, ALS).
Department:
Ophthalmology
Concentrations:
Accepting Students
Yes
Last Updated
1/13/2017 4:25:37 PM
Research Description
Optimizing gene therapy vectors (AAV) for the treatment of inherited retinal disease.
Department:
Psychiatry
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
Drug addiction is a chronic disorder that is characterized by compulsive drug taking and relapse after periods of abstinence. The research in our laboratory focuses on the development of non-addictive treatments for nicotine, alcohol, and opioid addiction
Department:
Neuroscience
Concentrations:
Accepting Students
Yes
Last Updated
5/24/2016 11:52:33 AM
Research Description
The principal aim of my research is to investigate how medial temporal lobe and frontal cortical structures involved in memory and high-level sensory perception are altered by advanced age and how nutrition and fitness can circumvent possible network impairments. Age-associated cognitive impairments do not result from alterations to brain structures in isolation. To fully understand cognitive aging, it is therefore imperative to examine how brain areas interact. A powerful tool for pin-pointing disruptions in the complex neural systems that produce cognitive dysfunction during normal aging is the careful analysis of behavior. Therefore, all of my research projects begin with an extensive cognitive test battery, including tests of spatial memory, working memory, stimulus recognition and sensory perception. Following, a careful characterization of behavior, the primary methods I use to assay the neurobiological basis of age-associated cognitive decline are single-cell imaging techniques and in vivo high-density recordings of single neurons from behaving rats. A strength of this approach is that the neurobiology of age-related memory loss is examined at multiple levels. Behavioral analysis along with advanced imaging and physiological techniques provides a multiplicative understanding of the loci of circuit disruptions by linking specific physiological features to cognitive performance.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Last Updated
5/23/2016 1:53:43 PM
Research Description
Research involves studies on neuroinflammatory mechanisms of blood-brain barrier disruption in ischemic stroke with emphasis on cyclooxygenases and prostanoid signaling.
Department:
Aging & Geriatrics Research
Concentrations:
Accepting Students
No
Last Updated
5/24/2016 12:05:56 PM
Research Description
Investigates the contribution of age-related increase in adiposity to declining physical and cognitive function and uses a variety of interventions in the reversal of this process including the role of the renin-angiotensin, diet,exercise, the dev of nove
Department:
Oral Surgery
Concentrations:
Accepting Students
No
Last Updated
5/23/2016 1:01:02 PM
Research Description
Molecular processes that lead to the establishment of chronic pain; alterations in function of the N-Methyl-D-Aspartate (NMDA) receptor and vanilloid receptor as a result of persistent peripheral stimulation.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Last Updated
6/10/2016
Research Description
The focus of my studies is to characterize how innate immune signaling modifies disease pathology and neurodegeneration in mouse models of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease and ALS. Knowledge from these studies will enable us to harness immune functions as potential disease modifying therapies for these diseases.
Department:
Pediatrics
Concentrations:
Accepting Students
No
Last Updated
6/10/2016 11:51:25 AM
Research Description
Department:
Oral Surgery
Concentrations:
Accepting Students
No
Last Updated
5/23/2016
Research Description
Cellular and Molecular Pain Research Using Whole Cell Patch Clamp Techniques in Rat DRG
Department:
Physiological Sciences
Concentrations:
Accepting Students
No
Last Updated
6/3/2016 9:41:22 AM
Research Description
The neural mechanisms of behavioral and reflex control of breathing. Respiratory sensation mechanisms in various patient populations. Cortical control of breathing. Respiratory rehabilitation in patients with lung disease, stroke, neuromuscular disease an
Department:
Neurology
Concentrations:
Accepting Students
No
Last Updated
6/1/2016
Research Description
His basic research interests centers on structural and neurochemical changes in human brain in aging and dementia and effects of traumatic brain injury (TBI). His clinical and translational research have centered on understanding the genetics, neuropsychiatric symptoms, neuroimaging, and treatment and prevention of AD.
Department:
Neurosurgery
Concentrations:
Accepting Students
No
Last Updated
5/24/2016
Research Description
Investigate the role of stem/precursor cells in normal brain function and in states of injury and disease such as cancer. Developing and enabling innovative technologies to identify and measure stem cell and cancer stem cell activity and explore new treatment strategies leading to translational therapeutic development.
Department:
Psychology
Concentrations:
Accepting Students
No
Last Updated
5/31/2016 9:17:21 AM
Research Description
Neurobiology of autism spectrum disorder; neurobiology of self-injurious behaviors.
Department:
Biomedical Engineering
Concentrations:
Accepting Students
Yes
Last Updated
6/10/2016
Research Description
Areas of current research activity include the following: (1) multimodal neuroimaging, (2) neuronal oscillations, (3) neuronal network analysis, and (4) cognitive neuroscience and cognitive impairments
Department:
Anesthesiology
Concentrations:
Accepting Students
Yes
Last Updated
6/10/2016 12:56:29 PM
Research Description
Investigation of the clinically relevant anti-oxidant and anti-inflammatory drugs using in vivo preclinical models and human biospecimens of ischemic and hemorrhagic strokes, traumatic brain injury, Alzheimer, and other neurological disorders
Department:
Pediatrics
Concentrations:
Accepting Students
No
Last Updated
6/1/2016 3:11:55 PM
Research Description
The phenomenon of genomic imprinting is the differential modification of the maternal and paternal genetic contributions to the zygote, resulting in the differential expression of parental alleles during development and in the adult. A disturbance in genomic imprinting can lead to various genetic diseases including Prader-Willi syndrome (PWS). Besides serving as a model for imprinting, PWS is a great model to understand obesity which is a hallmark feature of this condition.
Department:
Pediatrics
Concentrations:
Accepting Students
No
Last Updated
5/24/2016 3:04:49 PM
Research Description
Development and optimization of adeno-associated virus vectors for treatment of diseases with a neuromuscular phenotype.
Department:
Psychiatry
Concentrations:
Accepting Students
No
Last Updated
5/25/2016 2:08:03 PM
Research Description
Our work focuses on using neuroimaging to study the neural correlates of addiction in rodent models. Functional magnetic resonance imaging (fMRI) allows us to inspect in vivo brain activation in response to a variety of cognitive, emotional and drug stimuli
Department:
Neurosurgery
Concentrations:
Accepting Students
Yes
Last Updated
9/26/2016
Research Description
Dr. Flores joined the University of Florida faculty to become part of the Preston A. Wells Jr. Center for Brain Tumor Therapy in order to focus on developing novel approaches to target brain tumors. She has developed a pre-clinical platform that utilizes tumor-specific autologous immune cells to efficiently target intracranial tumors. Her research interests are primarily in determining biological interactions between various cellular compartments involved in adoptive immunotherapy. Her studies also focus on leveraging systemic toxicity of frequently practiced clinical treatments in order to further enhance anti-tumor efficacy of immunotherapy.
Department:
Neuroscience
Concentrations:
Accepting Students
Yes
Last Updated
5/24/2016 9:33:40 AM
Research Description
Combines behavioral characterization with biochemical, molecular, and electrophysiological techniques to obtain an integrated perspective of brain aging, from the molecular to cognitive level.
Department:
Pharmacodynamics
Concentrations:
Accepting Students
Yes
Last Updated
5/26/2016
Research Description
Neurophysiological mechanisms related to stress, aging, memory, epilepsy, and drug abuse.
Department:
Neuroscience
Concentrations:
Accepting Students
Yes
Last Updated
5/31/2016
Research Description
Understanding the cellular pathways and molecular interactions involved as underlying causes of neurodegenerative diseases, with special emphasis on Parkinsons disease.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
Pathogenesis and treatment of Alzheimers and other Neurodegenerative disease
Department:
Biomedical Engineering
Concentrations:
Accepting Students
Yes
Last Updated
5/25/2016
Research Description
Dr. Gunduz' research is focused on finding precursors to behavior and aftereffects of stimulation in neural networks through electrophysiology and bioimaging. Her lab aims to translate this knowledge into clinical diagnostic and therapeutic systems to improve quality of life of those suffering from neurological disorders. To this end, Dr. Gunduz works with many clinical populations, such as neurosurgical patients with epilepsy and movement disorders (Tourette’s syndrome, Parkinson’s Disease), as well as stroke patients undergoing neurorehabilitation.
Department:
Pharmacology & Therapeutics
Concentrations:
Accepting Students
Yes
Last Updated
6/1/2016 2:00:38 PM
Research Description
Neuroimmunopharmacology. Chemokines and chemokine receptors in brain tumors. Focus on glioblastoma and pharmacological targeting using pre-clinical animal models
Department:
Physiological Sciences
Concentrations:
Accepting Students
No
Last Updated
5/25/2016 12:19:05 PM
Research Description
Cardiovascular neurophysiology and neural mechanisms underlying hypertension.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
Interactions of neurotrophic factors, apoptosis-related genes, and antioxidants in fetal alcohol syndrome
Department:
Oral Surgery
Concentrations:
Accepting Students
No
Last Updated
6/3/2016 12:20:36 PM
Research Description
Sensory aging, neuropathic pains of aging; health services research.
Department:
Center for Movement Disorders and Neurorestoration
Concentrations:
Accepting Students
Yes
Last Updated
6/5/2015
Research Description
His current research interests involve the use of non-invasive neuromodulation in movement disorders and neuroimaging techniques to study network connectivity in Parkinson’s disease.
Department:
Psychiatry
Concentrations:
Accepting Students
No
Last Updated
6/29/2016
Research Description
1. Gene therapy using recombinant adeno-associated virus-based vectors for the treatment of brain and thyroid disorders 2. Parvovirus-host interactions

Brad Hoffman, Ph.D.

Department:
Pediatrics
Concentrations:
Accepting Students
Yes
Last Updated
12/8/2016 8:43:45 AM
Research Description
My research group is particularly interested in the mechanisms surrounding the generation of antigen-specific regulatory T-cells (Tregs), and the role they have in tolerance induction following gene transfer. Our major focus is aimed at exploiting the unique molecular and cellular mechanisms of liver-directed AAV gene therapy in order to re-establish immunological self-tolerance to a protein through the induction and expansion of antigen-specific regulatory T-cells. Through an innovative strategy, our group seeks to develop a clinically relevant therapy that will abrogate the progression of autoimmune neurological diseases such as Multiple Sclerosis.
Department:
Neurosurgery
Concentrations:
Accepting Students
Yes
Last Updated
5/23/2016 1:22:16 PM
Research Description
1. Study the inflammatory healing response in aneurysms and develop novel tissue-engineered treatments and devices for aneurysms, 2. Study the inflammatory pathways that lead to the development of cerebral aneurysms in a flow-chamber model as well as in vivo animal models
Department:
Neurosurgery
Concentrations:
Accepting Students
Yes
Last Updated
6/3/2016 3:48:53 PM
Research Description
Investigating treatment strategies for experimental and clinical models of spinal cord injury
Department:
Neurology
Concentrations:
Accepting Students
No
Last Updated
6/1/2016
Research Description
A majority of Dr. Jaffee's research has focused on traumatic brain injury and utilizing a multidisciplinary approach to developmental strategies for assessment and management. Dr. Jaffee has personal experience with initiatives to better understand blast injury and has an interest in studying long-term sequelae of traumatic brain injury and concussion. Dr. Jaffee also has an interest in the interface between neurologic disease and psychiatric symptoms and the interface between neurology and sleep.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Last Updated
5/31/2016 1:12:15 PM
Research Description
Focuses on behavioral development, cognitive function and decline in mouse models of neurodegenerative disorders and neural mechanisms underlying dementia.
Department:
Physiological Sciences
Concentrations:
Accepting Students
No
Last Updated
5/24/2016 11:46:57 AM
Research Description
In vivo/in vitro electrophysiology, neuroanatomy, and immunohistochemistry of the single sensory neurons, spinal cord and brainstem interneurons, and motoneurons of the somatosensory and visceral systems; role in peripheral nerve/spinal cord injury, urogenital dysfunction, visceral pain, diabetes.
Department:
Electrical and Computer Engineering
Concentrations:
Accepting Students
No
Last Updated
7/27/2016
Research Description
. Dr. Judy’s research involves the development of novel micro-electro-mechanical systems, such as microscale and nanoscale sensors, actuators, and systems, and their use in impactful engineering, scientific, biological, and medical, applications. A particular focus is in the field of neural-interface technology and systems, with applications in bi-directional prosthetic control, movement disorders, and the autonomic nervous system.
Department:
Pharmacodynamics
Concentrations:
Accepting Students
Yes
Last Updated
7/18/2016 8:49:20 AM
Research Description
My research interests are the adaptations in endocrine and cardiovascular systems in pregnancy and at birth. The current focus of my research is fetal and neonatal metabolism, including 1)the effect of glucocorticoids on fetal cardiac metabolism and function, and the transition at birth, 2) effects of exposure to Triclosan (an antibacterial in many soaps), and 3) alterations in the maternal microbiome. The laboratory uses a combination of in vivo techniques, including use of telemetry to measure fetal cardiovascular function in utero, biochemical techniques, and systems biology methods- both transcriptomics and metabolomics.
Department:
Pharmacology & Therapeutics
Concentrations:
Accepting Students
No
Last Updated
6/29/2016 8:05:51 AM
Research Description
Drug design based on naturally occurring toxins affecting brain nicotinic receptors; drug structure-activity relationships
Department:
Neuroscience
Concentrations:
Accepting Students
No
Last Updated
5/23/2016 11:28:49 AM
Research Description
We are studying how drugs of abuse such as methamphetamine, HIV infection or alpha-synuclein, a protein implicated in Parkinson’s Disease affect dopamine neurotransmission and thus synaptic plasticity.

Michael King

Department:
Pharmacology & Therapeutics
Concentrations:
Accepting Students
No
Last Updated
5/24/2016
Research Description
Neurodegenerative disease, CNS gene delivery, epilepsy, learning/memory.
Department:
Pharmacodynamics
Concentrations:
Accepting Students
No
Last Updated
6/29/2016 3:39:53 PM
Research Description
Stress, broadly defined as a real or perceived threat to homeostasis, activates neural circuits that alter the body’s physiology and behavior to ensure survival and well-being. The Krause Laboratory employs the rodent model to identify neuronal circuits that promote susceptibility or resiliency to stress.
Department:
Neuroscience
Concentrations:
Accepting Students
Yes
Last Updated
9/13/2016
Research Description
My research involves generation of anti-amyloid beta peptide single-chain variable fragments and administrating them to various neurodegenerative disease animal models via Adeno-Associated virus mediated gene transfer. I have cloned light and heavy chain units from several anti-Abeta, anti-tau, anti-alpha-synuclein antibodies available in the laboratory and nstructed a single chain Fv. Using a novel technique of AAV-mediated gene delivery into eonatal brain I express these scFv in transgenic mice in an attempt to attenuate amyloid deposition. Additionally, I am working on development of anti-generic amyloid single-chain fragments directed specifically against fibrillar Amyloid beta. For several years we have been attempting to dissect potential mechanisms involved in Abeta vaccination strategies for the therapy of AD using ransgenic mouse models. Recently we provided a framework to evaluate proposed mechanisms of Abeta attenuation mediated by peripheral administration of an anti-Abeta monoclonal antibody (mAb) effective in passive immunization paradigm. The data suggests that the mAbs are either indirectly enhancing clearance of Abeta or targeting a low abundance aggregation intermediate. Another path of research that I am pursuing is testing a new strategy to develop animal models that more closely resemble Alzheimer’s disease processes in the human brain. I will test the utility of a novel mechanism to deliver individual beta-amyloid protein fragments as well as other non-Abeta amyloidogenic peptides torodent brain and determine whether these models develop a brain pathology that closely resembles Alzheimer’s.
Department:
Psychiatry
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
Our lab studies the abnormal repetitive behavior diagnostic for autism and common in neurodevelopmental disorders. We employ mouse models to study the development and neurobiological basis of repetitive behavior using behavioral, pharmacological, biochemi
Department:
Neuroscience
Concentrations:
Accepting Students
Yes
Last Updated
5/24/2016 9:48:45 AM
Research Description
In vivo modeling and therapeutics for neurodegenerative diseases (ALS, AD, PD, FTD)
Department:
Neurology
Concentrations:
Accepting Students
No
Last Updated
5/23/2016 2:09:37 PM
Research Description
Dr. Li’s research is mainly focused on pathophysiology and experimental therapeutics of dystonia and restless legs syndrome. He is also broadly interested in animal models of movement disorders and in molecular and cellular mechanisms of synaptic plasticity during development and learning.
Department:
Whitney Laboratories
Concentrations:
Accepting Students
No
Last Updated
5/31/2016 1:42:19 PM
Research Description
Regulation of cell differentiation in the vertebrate retina and CNS and the molecular physiology of disease vector mosquito larvae. Molecular physiology of larval mosquito gut epithelium. Ageing of the cochlea.

Yijun Liu, Ph.D.

Department:
Psychiatry
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
Functional neuroimaging study of obesity, aging, brain injury and neuropsychiatric disorders.
Department:
Neurology
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
Neuroprotection in epileptogenesis
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
Yes
Last Updated
6/29/2016
Research Description
Interaction of proteins and membanes in regulating cell membrane biophysics and cell signalling; nuclear magnetic resonance (NMR);protein regulation of biofilm formation and biomineralization; methods to measure metabolism in vivo
Department:
Pediatrics
Concentrations:
Accepting Students
Yes
Last Updated
5/23/2016
Research Description
The research in my lab is focus on developing new therapies of lysosomal storage diseases (LSDs) based on the understanding of molecular mechanisms of the pathogenesis of these diseases. These inherited metabolic conditions are caused by defects in a wide spectrum of lysosomal and a few non-lysosomal proteins resulting in accumulation of undigested substrates, resulting in dysfunction of lysosomal/endosomal system. The almost 60 different LSDs are individually rare genetic conditions, but, collectively, the incidence is approximately 1/2,000-3,000 live births. Since lysosomal/endosomal system is essential for cell homeostasis, this “inborn organelle disorders” results in multi-systemic diseases, and predominantly affecting the brain. The study LSDs allowed the discovery of several biological processes including the discovery of mannose-6-phosphate targeting system and currently gives insights into neurodegenerative mechanism in Alzheimer and Parkinson’s diseases. In LSDs, the development of clinical symptoms usually correlates with a level of residual deficient enzyme activity. In patients with late onset forms of LSDs, a residual lysosomal activity is a result of missense mutations, which partially preserves catalytic enzyme function but mostly impairs the early folding process in the ER. These mutant lysosomal enzymes do not reach its appropriate conformation, and subsequently are directed to ER-associate degradation (ERAD) pathway, and are ultimately degraded by the ubiquitin-proteosome system. In this context, small molecule therapeutics are an attractive approach to treat LSDs. Enzyme-enhancement agents, including pharmacological chaperones (PC), are small molecules which are able to assist a mutant misfolded protein to achieve a native-like conformation in the endoplasmic reticulum (ER), allowing it to escape the ERAD pathway, and reach the lysosome. An advantage of this approach is that small molecules are much more likely to cross the blood brain barrier and reach neuronal cells, which are dramatically affected in LSDs. In addition, principles learned in treating one type of LSD can be applied not only to other LSDs, but also to other misconformation protein diseases, which is also feature of common neurodegenerative conditions.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Last Updated
6/9/2015 12:05:39 PM
Research Description
Application of gene transfer to study animal models of neurodegenerative disorders including Parkinson's disease, Alzheimer's disease, Huntington's disease, brain tumors, and ischemia.
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Last Updated
5/24/2016 11:19:51 AM
Research Description
1) The study of central nervous system structure and function with magnetic resonance; In particular, mapping of brain structural connectivity using diffusion-weighted magnetic resonance imaging methods and the mapping of functional connectivity with functional magnetic resonance imaging.

Mark Q. Martindale, Ph.D.

Department:
Whitney Laboratories
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
Director of the Whitney Laboratory for Marine Bioscience and renowned scientist. His research focus is aimed at elucidating the cellular and molecular basis for the evolution of cell-type complexity.
Department:
Physiological Sciences
Concentrations:
Accepting Students
No
Last Updated
6/13/2016 11:39:20 AM
Research Description
toxicology, sex steroids, neuroendocrinology, gamma-aminobutyric acid, transcriptomics, proteomics, reproduction
Department:
Anesthesiology
Concentrations:
Accepting Students
No
Last Updated
6/3/2016 4:20:16 PM
Research Description
Mechanisms of long-term central and systemic abnormalities induced by neonatal exposure to general anesthesia. Mechanisms underlying the causes of epilepsy in phenylketonuria (PKU).

Mathew, Carol M.D.

Department:
Psychiatry
Concentrations:
Accepting Students
Yes
Last Updated
5/23/2016
Research Description
Our group studies how genes, environment, and culture interact to influence human emotion and behavior. In particular, we focus on how these factors affect the development and expression of neuropsychiatric syndromes, including anxiety, resilience, ADHD, OCD, compulsive hoarding, and tic disorders. Approaches include neuropsychological, electrophysiological, and physiological approaches, as well as functional neuroimaging.
Department:
Neuroscience
Concentrations:
Accepting Students
Yes
Last Updated
6/3/2016
Research Description
Oscillations are prominent in all realms of the physical and biological world. Clocks tick, fire flies flash and neurons of the brain ‘fire’ action potentials. While it is known that two clocks on a wall will synchronize their pendulums and specific species of fire flies will phase lock their flashes, the basic mechanisms of how large populations of neurons interact in a coordinated manner to enable a rich repertoire of adaptive behaviors is relatively unknown. Specifically, we have a limited understanding on how neurons self-organize their activity to produce the synchrony that is needed to transfer information across large-scale neural networks. Moreover, even less is known regarding how information is transformed and updated as it propagates across the brain. Theoretically, it is the oscillatory rhythms of the brain, along with the synaptic architecture, that allow neurons to transiently synchronize and desynchronize their activity, optimizing nimble computations at the “speed of thought”. Fortunately, we have reached a technological threshold that has permitted the testing of theoretical models on large amounts of neural data. Therefore, my research seeks to understand how the brain, a densely interconnected set of individual neurons, rapidly translates environmental information into complex representations in support of cognitive function. In order to achieve these goals, my collaborators and I have embarked on a unique research trajectory that will allow us to test the hypotheses of complex network activity using both a bottom-up approach, inspired by computational models, and a top-down approach, re-evaluating our data in the perspective of non-linear physics. It is our expectation that, by adopting an integrative approach that bridges disciplines, we can learn how the small actions of single neurons, connected in a network can bring about the emergence of sophisticated dynamics that support behavior and higher cognitive function. Moreover, by examining neural processing on multiple scales, from small groups of isolated cells to the population dynamics of entire brain regions, we believe that we will find a common etiology of how coordinated activity emerges that can be extended into the larger field of complexity.” “We also have a research track investigating the changes in neuronal dynamics behind age-related decline in memory and cognition. Along with my collaborators in McKnight Brain Institute in the Age-Related Memory Loss group, we seek to find therapeutic interventions that maximize longevity and neuronal processing in hopes of maintaining independence in the elderly population.
Department:
Neurology
Concentrations:
Accepting Students
No
Last Updated
5/31/2016 1:01:51 PM
Research Description
My research focuses on understanding the pathological mechanisms of Parkinson disease and related disorders, and in particular the role that abnormal protein accumulation, such alpha synuclein, plays in these disorders.
Department:
Neuroscience
Concentrations:
Accepting Students
Yes
Last Updated
5/23/2016
Research Description
Olfactory disorders affect a significant portion of the population. In addition to other sensory defects, channelopathies have been shown to cause the loss of the sense of smell. My lab seeks to apply gene therapy approaches to correct these channel defects and restore olfactory function for the further development of treatments for human patients. Additionally, my lab studies the role of primary cilia on the neurons present in the olfactory bulb. The precise roles for these organelles on neurons in the brain remain unknown. Many of these cilia possess G-protein coupled receptors for neuromodulatory signals. The aim of this project is to elucidate the role for cilia in modulating neuronal function in the olfactory bulb.
Department:
Physical Therapy
Concentrations:
Accepting Students
No
Last Updated
6/29/2016
Research Description
Our research is focused on cellular mechanisms of spinal motor plasticity, particularly plasticity elicited by intermittent exposure to low oxygen (intermittent hypoxia). We explore the ability to harness intermittent hypoxia induced plasticity to improve respiratory and non-respiratory motor function in rodent models of spinal injury and motor neuron disease. We also investigate: 1) the impact of age, sex, genetics and inflammation on spinal plasticity; 2) combinatorial strategies including pharmacological, rehabilitation and stem cell based therapies; 3) the ability to harness intermittent hypoxia to treat persons with diverse clinical disorders that compromise neuromuscular function; and 4) are beginning to explore the potential of intermittent hypoxia to elicit brain plasticity and enhance learning and memory.
Department:
Neurosurgery
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
Department:
Psychiatry
Concentrations:
Accepting Students
No
Last Updated
5/25/2016 3:43:34 PM
Research Description
Behavioral effects of drug of abuse used recreationally (e.g. cocaine) and medicinally (e.g. opioid painkillers) in rats.
Department:
Whitney Laboratories
Concentrations:
Accepting Students
Yes
Last Updated
6/6/2016 11:50:20 AM
Research Description
Genomic Bases of Memory and Neuronal Evolution. Our laboratory works to characterize basic mechanisms underlying the design of nervous systems and evolution of neuronal signaling mechanisms. The major questions are: (1) why are individual neurons so different? (2) How do learning and memory store in neuronal genomes and neural circuits? (3) How to restore memories? (4) How to make a neuron and a brain?
Department:
Pharmacology & Therapeutics
Concentrations:
Accepting Students
Yes
Last Updated
5/23/2016
Research Description
We study the molecular basis of chemodetection in olfactory, taste, and endocrine systems, including how diverse receptor and signaling mechanisms contribute to chemosensory function, impact ingestive and social behaviors, and interact with metabolic systems.
Department:
Orthodontics
Concentrations:
Accepting Students
No
Last Updated
6/3/2016 9:53:20 AM
Research Description
Neurophysiology of pain; inflammation and neuropathic pain; chronic pain mechanisms; translational research for chronic pain.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Last Updated
6/1/2016
Research Description
Our research focuses on understanding the underlying molecular mechanisms controlling gene expression in the inflammatory response and in the etiology of Type 1 Diabetes.
Department:
Psychiatry
Concentrations:
Accepting Students
No
Last Updated
6/3/2016 12:22:31 PM
Research Description
Neurocognitive processes associated with acute and chronic substance use, effects of aging, gender differences
Department:
Neuroscience
Concentrations:
Accepting Students
Yes
Last Updated
6/1/2016 3:02:22 PM
Research Description
Studies on the cellular and molecular bases for inherited peripheral neuropathies and approaches to attenuate the accumulation of misfolded proteins within cells. Schwann cell biology, myelin formation, small molecule therapies and dietary approaches
Department:
Neurology
Concentrations:
Accepting Students
Yes
Last Updated
6/1/2016 2:50:57 PM
Research Description
Dr. Okun’s laboratory has focused on identifying the physiological brain signature patterns for tics and other movement disorders, and also has been focused on the development of neurotechnology for a closed loop solution to tic disorders. Dr. Okun’s research efforts have also been focused on the motor and non-motor aspects of deep brain stimulation as applied to basal ganglia disorders.
Department:
Biomedical Engineering
Concentrations:
Accepting Students
No
Last Updated
5/31/2016 12:45:56 PM
Research Description
Studies how stem cell strategies could be used to repair the brain. We use the hippocampus as a model to understand how make the brain receptive to neuron addition because the hippocampus adds new neurons throughout life in all mammals, including humans
Department:
Biomedical Engineering
Concentrations:
Accepting Students
No
Last Updated
5/24/2016
Research Description
Neural engineering. Sensory repair and prostheses . Brain-machine interfaces. Sensation induced by activation of neural tissue. Neural coding and plasticity.
Department:
Electrical and Computer Engineering
Concentrations:
Accepting Students
No
Last Updated
7/27/2016
Research Description
Sensorimotor Integration, Systems & Computational Neuroscience, Neural interfaces
Department:
Pharmacology & Therapeutics
Concentrations:
Accepting Students
No
Last Updated
5/23/2016
Research Description
Physiology, pharmacology, and biophysics of neurotransmitter receptors especially the function of nicotinic acetylcholine receptors in the brain.
Department:
Physiology & Functional Genomics
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
Signal transduction mechanism of angiotensin regulation of norepinephrine neuromodulation in the brain; antisense targating of renin/angiotensin to control cardiovascular diseases; gene therapy, neurobiology, brain cytokines in neurogenic hypertension.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Last Updated
11/12/2015 11:27:22 AM
Research Description
Uses human genetics studies to define the molecular causes of neurological and neuromuscular disease and animal models to understand how disease-causing mutations affect neuronal function.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Last Updated
6/14/2016
Research Description
Regeneration in CNS and PNS with emphasis on neural tissue transplantation and spinal cord injury and repair; cell biology of neurons and glia in the developing and injured spinal cord.
Department:
Neurosurgery
Concentrations:
Accepting Students
No
Last Updated
6/1/2016 3:42:28 PM
Research Description
Characterization and manipulation of adult neural stem cells.
Department:
Neurology
Concentrations:
Accepting Students
No
Last Updated
6/10/2016
Research Description
My laboratory applies a variety of techniques to study the molecular pathways associated with several neurodegenerative diseases and to discover potential therapeutic targets. To do so, we use a multidisciplinary approach combining Drosophila genetics, neuroscience, molecular biology, biochemistry and optogenetic technologies.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Last Updated
6/3/2016
Research Description
Structural and functional organization of the normal and injured spinal cord.
Department:
Neurosurgery
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
Cellular basis of epilepsy.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Last Updated
5/31/2016 12:34:09 PM
Research Description
Cellular and molecular mechanisms underlying normal and pathogenetic development of the cerebral cortex.
Department:
Neurosurgery
Concentrations:
Accepting Students
No
Last Updated
5/31/2016
Research Description
Current interests include developing innovative immunotherapeutics for pediatric tumors and invasive central nervous system malignancies. Dr. Sayour’s main focus is deeply rooted in harnessing the immune system to eradicate pediatric cancers. He has received several extramural grants to support his research efforts including the Hyundai Hope on Wheels Hope Award, ASPHO Young Investigator Award, and the American Brain Tumor Association Discovery Award. Dr. Sayour has been involved in translating bench work into clinical trials governing the development of dendritic cell vaccines with adoptively transferred cytotoxic T cells against recurrent medulloblastoma. He has also started an integrative pediatric immunotherapy working group at UF that includes surgeons, clinicians, veterinarians, and pre-clinical scientists working to advance novel directed therapeutics against refractory malignancies. Their goals are to identify novel antigen targets and construct robust immunotherapeutic treatments against these malignancies.
Department:
Physiology & Functional Genomics
Concentrations:
Accepting Students
No
Last Updated
6/1/2016 12:31:28 PM
Research Description
Effects of stress and chronic elevations in glucocorticoids on central nervous system control of cardiovascular function.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Last Updated
5/24/2016 3:47:29 PM
Research Description
Inherited Photoreceptor disease, viral vector-based gene therapy, and photoreceptor biology. My current focus is online and hybrid graduate instruction.
Department:
Psychiatry
Concentrations:
Accepting Students
Yes
Last Updated
5/31/2016 12:34:53 PM
Research Description
Behavioral, pharmacological and neurobiological basis of decision-making, particulary in relation to addiction and other psychiatric conditions. We employ a range of techniques in our lab, including analyses of complex behavior, behavioral pharmacology, optogenetics, and in vivo electrophysiological recording.
Department:
Ophthalmology
Concentrations:
Accepting Students
No
Last Updated
5/25/2016 12:18:31 PM
Research Description
Molecular biology and biochemistry of vision in vertebrates and invertebrates.
Department:
Community Dentistry and Behavioral Science
Concentrations:
Accepting Students
No
Last Updated
6/1/2015 4:09:11 PM
Research Description
Psychophysical measurement with an emphasis on taste and other oral sensations. Associations between the sensory properties of foods and health.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Last Updated
5/31/2016 3:40:34 PM
Research Description
Neuroimmunology and experimental neuropathology. Neurobiology of microglial cells.
Department:
Physiology & Functional Genomics
Concentrations:
Accepting Students
No
Last Updated
6/10/2015 9:23:33 AM
Research Description
Hypertension; Stroke
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Last Updated
6/3/2016 11:19:18 AM
Research Description
Mouse models for neurological disease;RNA processing, transport and turnover; molecular mechanisms of mammalian development and aging
Department:
Neurosurgery
Concentrations:
Accepting Students
No
Last Updated
4/11/2016
Research Description
My research program is focused understanding the mechanism of cancer metastasis and dormancy. The epithelial mesenchymal transition (EMT) is now suggested to play an important role in the initial invasion during cancer metastasis. However, direct in vivo evidence is currently lacking. Our lab is interested in understanding how cancer EMT contributes to cancer metastasis, and if so whether it also regulates cancer dormancy, a phenomenon in which micrometastatic disease is present in multiple organs but clinically undetectable.
Department:
Pharmacology & Therapeutics
Concentrations:
Accepting Students
No
Last Updated
6/10/2016 12:44:11 PM
Research Description
Oxidative stress, Aging and central regulation of blood pressure.
Department:
Physiological Sciences
Concentrations:
Accepting Students
No
Last Updated
5/24/2016 12:01:59 PM
Research Description
Drug use in food producing animals; pharmacokinetic modelling
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
Yes
Last Updated
5/31/2016 4:37:29 PM
Research Description
The Vitriol lab uses live cell and super resolution microscopy to study the actin cytoskeleton in cell motility, neural development, and neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS).

Aparna Ashutosh Wagle Shukla

Department:
Neurology
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
Department:
Psychiatry
Concentrations:
Accepting Students
Yes
Last Updated
6/29/2016
Research Description
Protease overactivation in central nervous system diseases; Tauopathy/proteinopathy, biomarkers, proteomics for traumatic brain injury, spinal cord injury, substance abuse, exosome
Department:
Neurology
Concentrations:
Accepting Students
No
Last Updated
5/24/2016
Research Description
Dr. Williamson has completed a clinical fellowship in neuropsychology and research fellowship in neuroscience. His research includes central and peripheral nervous system interactions in regulating behavior including cognition and emotion. He has active projects in cardiovascular disease contributions to cognitive impairment, traumatic brain injury and emotional dysregulation, and the application of noninvasive nerve stimulation technologies to modify cognitive and emotional performance.
Department:
Physiology & Functional Genomics
Concentrations:
Accepting Students
Yes
Last Updated
5/24/2016
Research Description
Fetal neuroendocrine development and cardiovascular physiology.
Department:
Medicine
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
Department:
Medicine
Concentrations:
Accepting Students
No
Last Updated
5/31/2016 2:02:24 PM
Research Description
electrophysiological property of non-excitable cells; intercellular & intracellular calcium signaling pathways; functional role of purinergic signaling in the kidney; functional role of P2X & P2Y receptors in SGK1-regulated ion transport.
Department:
Medicine-Jax
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
Role of H+ V-ATPase and novel secondary transporter Na+ or K+/H+ antiporter
Department:
Pediatrics
Concentrations:
Accepting Students
No
Last Updated
7/24/2015
Research Description
Clinical genetics and cytogenetics, neurodevelopmental diseases.

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