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Department:
Whitney Laboratories
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/15/2017 12:39:53 PM
Research Description
Chemical senses, sensory physiology, invertebrate neurobiology.
Department:
Otolaryngology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2017 8:00:52 AM
Research Description
Hearing loss and facial paralysis: prevention and treatment
Department:
Ophthalmology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/6/2017
Research Description
Research is focused on mechanisms of inherited retinal degeneration and neuroprotection. His most recent studies have shown the important contribution of endogenously expressed cytokines such as leukemia inhibitory factor (LIF)
Department:
Neuroscience
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/12/2017
Research Description
My lab is focused on elucidating the mechanisms involved in the onset and propagation of neurodegenerative diseases. Over the last decade, a number of studies have implicated a prion-like mechanism for the accumulation and dissemination of proteins involved in Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis (ALS), among others. Taking a page from studies performed in the prion field, we have used both cell and animal models of these disorders to reveal that similar to the prion protein, these toxic misfolded proteins can template their structure onto natively folded proteins, thereby causing an accumulation of pathological inclusions. Additionally, we have demonstrated the ability for misfolded proteins implicated in ALS and Parkinson’s Disease to propagate throughout the central nervous system along known neuroanatomical pathways, most likely via axonal connections. By better understanding these properties, our hope is to develop therapies to prevent and/or stop the spread of these debilitating diseases.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/29/2017 12:34:28 PM
Research Description
Molecular mechanisms of age related cognitive decline
Department:
Neuroscience
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/22/2015
Research Description
Develop technology and application of magnetic resource imaging and spectroscopy.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017 11:01:32 AM
Research Description
Molecular pathogenesis of the herpesviruses; role of long non-coding RNAs and miRNAs on latency and reactivation; development of novel therapeutics to disrupt HSV latency and block recurrent disease.
Department:
Physiological Sciences
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
7/6/2017
Research Description
A variety of neuromuscular diseases result in impaired cough (dystussia) and/or impaired swallow function (dysphagia). Cough and swallows are controlled by complex brainstem networks which, until recently, have been studied in isolation. However, in neuro
Department:
Neuroscience
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/12/2017 12:51:04 PM
Research Description
My lab uses transgenic & knockout mouse models, and cell models, to determine molecular mechanisms by which mutations in specific genes cause familial neurodegenerative diseases - primarily Alzheimer's disease and amyotrophic lateral sclerosis.
Department:
Physiological Sciences
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/7/2017 1:58:03 PM
Research Description
Understanding the molecular-physiological-through-behavioral neurobiology of motor, sensory and cognitive plasticity following pharmacotherapy and neurorehabilitation using preclinical (rodent) models of neurotrauma (spinal cord, traumatic brain injuries, stroke) and neurodegenerative diseases.
Department:
Ophthalmology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017 4:25:37 PM
Research Description
Optimizing gene therapy vectors (AAV) for the treatment of inherited retinal disease.
Department:
Psychiatry
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/22/2015
Research Description
Drug addiction is a chronic disorder that is characterized by compulsive drug taking and relapse after periods of abstinence. The research in our laboratory focuses on the development of non-addictive treatments for nicotine, alcohol, and opioid addiction
Department:
Neuroscience
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/6/2017 11:52:33 AM
Research Description
The principal aim of my research is to investigate how medial temporal lobe and frontal cortical structures involved in memory and high-level sensory perception are altered by advanced age and how nutrition can circumvent possible network impairments.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/15/2017 1:53:43 PM
Research Description
Research involves studies on neuroinflammatory mechanisms of blood-brain barrier disruption in ischemic stroke with emphasis on cyclooxygenases and prostanoid signaling.
Department:
Aging & Geriatrics Research
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2017 12:05:56 PM
Research Description
Investigates the contribution of age-related increase in adiposity to declining physical and cognitive function and uses a variety of interventions in the reversal of this process including the role of the renin-angiotensin, diet,exercise, the dev of nove
Department:
Oral Surgery
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2017 1:01:02 PM
Research Description
Molecular processes that lead to the establishment of chronic pain; alterations in function of the N-Methyl-D-Aspartate (NMDA) receptor and vanilloid receptor as a result of persistent peripheral stimulation.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/26/2017
Research Description
The focus of my studies is to characterize how innate immune signaling modifies disease pathology and neurodegeneration in mouse models of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease and ALS.
Department:
Pediatrics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/10/2016 11:51:25 AM
Research Description
Department:
Oral Surgery
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
7/6/2017
Research Description
Cellular and Molecular Pain Research Using Whole Cell Patch Clamp Techniques in Rat DRG
Department:
Physiological Sciences
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/12/2017 9:41:22 AM
Research Description
The neural mechanisms of behavioral and reflex control of breathing. Respiratory sensation mechanisms in various patient populations. Cortical control of breathing. Respiratory rehabilitation in patients with lung disease, stroke, neuromuscular disease an
Department:
Neurology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2017
Research Description
His basic research interests centers on structural and neurochemical changes in human brain in aging and dementia and effects of traumatic brain injury (TBI). His clinical and translational research have centered on genetics, neuropsychiatric, neuroimaging and therapeutic trials to prevent and treat Alzheimer’s disease, age related memory loss, and traumatic brain injury.
Department:
Neurosurgery
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017
Research Description
Investigate the role of stem/precursor cells in normal brain function and in states of injury and disease such as cancer. Developing and enabling innovative technologies to identify and measure stem cell and cancer stem cell activity and explore new treatment strategies leading to translational therapeutic development.
Department:
Psychology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
5/31/2016 9:17:21 AM
Research Description
Neurobiology of autism spectrum disorder; neurobiology of self-injurious behaviors.
Department:
Ophthalmology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/27/2017
Research Description
Dr. Dinculescu received her Ph.D. in Biochemistry from University of Florida in 2002. Her research is focused on understanding the molecular mechanisms in several retinal degeneration disorders, including Usher syndrome. The ultimate goal is to develop therapeutic strategies to prevent the loss of sight caused by these disorders. Usher syndrome type III (USH3A), an autosomal recessive disorder, is caused by mutations in Clarin-1 (CLRN1) protein, leading to combined vision and hearing loss. The main goal of this project is to understand the function of CLRN1 in the retina, identify its binding partners, and its cellular localization pattern. This information will be used to develop a rational treatment for the USH3A disorder. She is also interested in protein aggregation mechanisms leading to the formation of extracellular deposits associated with vision loss in age-related macular degeneration, a major cause of blindness in the elderly population.
Department:
Biomedical Engineering
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
6/10/2016
Research Description
Areas of current research activity include the following: (1) multimodal neuroimaging, (2) neuronal oscillations, (3) neuronal network analysis, and (4) cognitive neuroscience and cognitive impairments
Department:
Anesthesiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017 12:56:29 PM
Research Description
Investigation of the clinically relevant anti-oxidant and anti-inflammatory drugs using in vivo preclinical models and human biospecimens of ischemic and hemorrhagic strokes, traumatic brain injury, Alzheimer, and other neurological disorders
Department:
Pediatrics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2017 3:11:55 PM
Research Description
The phenomenon of genomic imprinting is the differential modification of the maternal and paternal genetic contributions to the zygote, resulting in the differential expression of parental alleles during development and in the adult. A disturbance in genomic imprinting has been found to cause several human diseases including Prader-Willi and Angelman syndromes.
Department:
Pediatrics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/26/2017 3:04:49 PM
Research Description
Our laboratory focuses on two distinct but unified research concentrations. These areas include 1) gene therapy for monogenetic disease(s) that affect normal function of motoneurons and skeletal muscle and 2) incorporation of optogenetics to enhance rehabilitation of the neuromuscular system following injury.
Department:
Psychiatry
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/5/2017 2:08:03 PM
Research Description
Our work focuses on using neuroimaging to study the neural correlates of addiction in rodent models. Functional magnetic resonance imaging (fMRI) allows us to inspect in vivo brain activation in response to a variety of cognitive, emotional and drug stimuli
Department:
Neurosurgery
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
9/26/2016
Research Description
Dr. Flores joined the University of Florida faculty to become part of the Preston A. Wells Jr. Center for Brain Tumor Therapy in order to focus on developing novel approaches to target brain tumors. She has developed a pre-clinical platform that utilizes tumor-specific autologous immune cells to efficiently target intracranial tumors. Her research interests are primarily in determining biological interactions between various cellular compartments involved in adoptive immunotherapy. Her studies also focus on leveraging systemic toxicity of frequently practiced clinical treatments in order to further enhance anti-tumor efficacy of immunotherapy.
Department:
Neuroscience
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017 9:33:40 AM
Research Description
Combines behavioral characterization with biochemical, molecular, and electrophysiological techniques to obtain an integrated perspective of brain aging, from the epigenetic and physiological level to cognitive level.
Department:
Pharmacodynamics
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
5/26/2016
Research Description
Neurophysiological mechanisms related to stress, aging, memory, epilepsy, and drug abuse.
Department:
Neuroscience
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017
Research Description
Understanding the cellular pathways and molecular interactions involved as underlying causes of neurodegenerative diseases, with special emphasis on Parkinsons disease.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/22/2015
Research Description
Pathogenesis and treatment of Alzheimers and other Neurodegenerative disease
Department:
Biomedical Engineering
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/12/2017
Research Description
Dr. Gunduz' research is focused on finding precursors to behavior and aftereffects of stimulation in neural networks through electrophysiology and bioimaging. Her lab aims to translate this knowledge into clinical diagnostic and therapeutic systems to improve quality of life of those suffering from neurological disorders. To this end, Dr. Gunduz works with many clinical populations, such as neurosurgical patients with epilepsy and movement disorders (Tourette’s syndrome, Parkinson’s Disease), as well as stroke patients undergoing neurorehabilitation.
Department:
Pharmacology & Therapeutics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/26/2017 2:00:38 PM
Research Description
Neuroimmunopharmacology. Chemokines and chemokine receptors in brain tumors. Focus on glioblastoma and pharmacological targeting using pre-clinical animal models
Department:
Physiological Sciences
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2017 12:19:05 PM
Research Description
Cardiovascular neurophysiology and neural mechanisms underlying hypertension.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/26/2017
Research Description
Interactions of neurotrophic factors, apoptosis-related genes, and antioxidants in fetal alcohol syndrome
Department:
Oral Surgery
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/15/2017 12:20:36 PM
Research Description
Sensory aging, neuropathic pains of aging; health services research.
Department:
Center for Movement Disorders and Neurorestoration
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
6/5/2015
Research Description
His current research interests involve the use of non-invasive neuromodulation in movement disorders and neuroimaging techniques to study network connectivity in Parkinson’s disease.
Department:
Psychiatry
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/29/2016
Research Description
1. Gene therapy using recombinant adeno-associated virus-based vectors for the treatment of brain and thyroid disorders 2. Parvovirus-host interactions

Brad Hoffman, Ph.D.

Department:
Pediatrics
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
7/6/2017 8:43:45 AM
Research Description
My research group is immunology based. We are currently developing a viral gene therapy that is capable of inducing of antigen-specific regulatory T-cells (Tregs) that target myelin based proteins as a means to treat/reverse the autoimmune response associated with Multiple Sclerosis.
Department:
Neurosurgery
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/12/2017 1:22:16 PM
Research Description
1. Study the inflammatory healing response in aneurysms and develop novel tissue-engineered treatments and devices for aneurysms, 2. Study the inflammatory pathways that lead to the development of cerebral aneurysms in a flow-chamber model as well as in vivo animal models
Department:
Neurology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/1/2016
Research Description
A majority of Dr. Jaffee's research has focused on traumatic brain injury and utilizing a multidisciplinary approach to developmental strategies for assessment and management. Dr. Jaffee has personal experience with initiatives to better understand blast injury and has an interest in studying long-term sequelae of traumatic brain injury and concussion. Dr. Jaffee also has an interest in the interface between neurologic disease and psychiatric symptoms and the interface between neurology and sleep.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/15/2017 1:12:15 PM
Research Description
Focuses on behavioral development, cognitive function and decline in mouse models of neurodegenerative disorders and neural mechanisms underlying dementia.
Department:
Physiological Sciences
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/26/2017 11:46:57 AM
Research Description
In vivo/in vitro electrophysiology, neurotracing, and immunohistochemical phenotyping of the visceral and somatic sensory neurons, spinal cord and brainstem interneurons, and motoneurons; role in peripheral nerve/spinal cord injury and visceral disease (diabetes, hypertension), and chronic deep tissue pain. New grants are on neuromodulation of visceral nerves with novel implanted neurostimulation devices.
Department:
Electrical and Computer Engineering
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/6/2017
Research Description
Dr. Judy’s research involves the development and use of state-of-the-art engineering technologies to advance fundamental neuroscientific understanding and to create effective neurological therapies. A particular focus of his research in on advance neural interfaces for acute and chronic applications as well as wearable sensing systems.
Department:
Pediatrics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/26/2017
Research Description
Dr. Kang’s laboratory focuses on the genetics of muscular dystrophy and the pathogenesis of disease in MEGF10 myopathy. Ultimately, these studies are expected to help identify novel therapeutic strategies for these diseases.
Department:
Pharmacodynamics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/26/2017 8:49:20 AM
Research Description
My research interests are the adaptations in endocrine and cardiovascular systems in pregnancy and at birth. The current focus of my research is fetal and neonatal metabolism, including 1)the effect of glucocorticoids on fetal cardiac metabolism and function, and the transition at birth, 2) effects of exposure to Triclosan (an antibacterial in many soaps), and 3) alterations in the maternal microbiome. The laboratory uses a combination of in vivo techniques, including use of telemetry to measure fetal cardiovascular function in utero, biochemical techniques, and systems biology methods- both transcriptomics and metabolomics.
Department:
Pharmacology & Therapeutics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/29/2016 8:05:51 AM
Research Description
Drug design based on naturally occurring toxins affecting brain nicotinic receptors; drug structure-activity relationships
Department:
Neuroscience
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017 11:28:49 AM
Research Description
We are studying how drugs of abuse such as methamphetamine, HIV infection or alpha-synuclein, a protein implicated in Parkinson’s Disease affect dopamine neurotransmission and thus synaptic plasticity.
Department:
Pharmacology & Therapeutics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/26/2017
Research Description
Neurodegenerative disease, CNS gene delivery, epilepsy, learning/memory.
Department:
Pharmacodynamics
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/26/2017 3:39:53 PM
Research Description
The Krause laboratory uses genetically modified mice to identify neuronal circuits that promote susceptibility or resiliency to stress-related disease.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/26/2017
Research Description
My research involves generation of anti-amyloid beta peptide single-chain variable fragments and administrating them to various neurodegenerative disease animal models via Adeno-Associated virus mediated gene transfer. I have cloned light and heavy chain units from several anti-Abeta, anti-tau, anti-alpha-synuclein antibodies available in the laboratory and nstructed a single chain Fv. Using a novel technique of AAV-mediated gene delivery into eonatal brain I express these scFv in transgenic mice in an attempt to attenuate amyloid deposition. Additionally, I am working on development of anti-generic amyloid single-chain fragments directed specifically against fibrillar Amyloid beta. For several years we have been attempting to dissect potential mechanisms involved in Abeta vaccination strategies for the therapy of AD using ransgenic mouse models. Recently we provided a framework to evaluate proposed mechanisms of Abeta attenuation mediated by peripheral administration of an anti-Abeta monoclonal antibody (mAb) effective in passive immunization paradigm. The data suggests that the mAbs are either indirectly enhancing clearance of Abeta or targeting a low abundance aggregation intermediate. Another path of research that I am pursuing is testing a new strategy to develop animal models that more closely resemble Alzheimer’s disease processes in the human brain. I will test the utility of a novel mechanism to deliver individual beta-amyloid protein fragments as well as other non-Abeta amyloidogenic peptides torodent brain and determine whether these models develop a brain pathology that closely resembles Alzheimer’s.
Department:
Neuroscience
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
6/12/2017
Research Description
In vivo modeling and therapeutics for neurodegenerative diseases (ALS, AD, PD, FTD)
Department:
Psychiatry
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2017
Research Description
Our lab studies the abnormal repetitive behavior diagnostic for autism and common in neurodevelopmental disorders. We employ mouse models to study the development and neurobiological basis of repetitive behavior using behavioral, pharmacological, biochemi
Department:
Neurology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
6/12/2017 2:09:37 PM
Research Description
Dr. Li’s research is mainly focused on pathophysiology and experimental therapeutics of dystonia and restless legs syndrome. He is also broadly interested in animal models of movement disorders and in molecular and cellular mechanisms of synaptic plasticity
Department:
Whitney Laboratories
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/26/2017 1:42:19 PM
Research Description
Regulation of cell differentiation in the vertebrate retina and CNS and the molecular physiology of disease vector mosquito larvae. Molecular physiology of larval mosquito gut epithelium. Ageing of the cochlea.

Yijun Liu, Ph.D.

Department:
Psychiatry
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/22/2015
Research Description
Functional neuroimaging study of obesity, aging, brain injury and neuropsychiatric disorders.
Department:
Neurology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/22/2015
Research Description
Neuroprotection in epileptogenesis
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/26/2017
Research Description
Protein regulation of biofilm formation and biomineralization; methods to measure metabolism in vivo; nuclear magnetic resonance (NMR); Interaction of proteins and membanes in regulating cell membrane biophysics
Department:
Pediatrics
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/12/2017
Research Description
The research in my lab is focus on developing new therapies of lysosomal storage diseases (LSDs) based on the understanding of molecular mechanisms of the pathogenesis of these diseases. These inherited metabolic conditions are caused by defects in a wide spectrum of lysosomal and a few non-lysosomal proteins resulting in accumulation of undigested substrates, resulting in dysfunction of lysosomal/endosomal system. The almost 60 different LSDs are individually rare genetic conditions, but, collectively, the incidence is approximately 1/2,000-3,000 live births. Since lysosomal/endosomal system is essential for cell homeostasis, this “inborn organelle disorders” results in multi-systemic diseases, and predominantly affecting the brain. The study LSDs allowed the discovery of several biological processes including the discovery of mannose-6-phosphate targeting system and currently gives insights into neurodegenerative mechanism in Alzheimer and Parkinson’s diseases. In LSDs, the development of clinical symptoms usually correlates with a level of residual deficient enzyme activity. In patients with late onset forms of LSDs, a residual lysosomal activity is a result of missense mutations, which partially preserves catalytic enzyme function but mostly impairs the early folding process in the ER. These mutant lysosomal enzymes do not reach its appropriate conformation, and subsequently are directed to ER-associate degradation (ERAD) pathway, and are ultimately degraded by the ubiquitin-proteosome system. In this context, small molecule therapeutics are an attractive approach to treat LSDs. Enzyme-enhancement agents, including pharmacological chaperones (PC), are small molecules which are able to assist a mutant misfolded protein to achieve a native-like conformation in the endoplasmic reticulum (ER), allowing it to escape the ERAD pathway, and reach the lysosome. An advantage of this approach is that small molecules are much more likely to cross the blood brain barrier and reach neuronal cells, which are dramatically affected in LSDs. In addition, principles learned in treating one type of LSD can be applied not only to other LSDs, but also to other misconformation protein diseases, which is also feature of common neurodegenerative conditions.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/12/2017 12:05:39 PM
Research Description
Application of gene transfer to study animal models of neurodegenerative disorders including Parkinson's disease, Alzheimer's disease, Huntington's disease, brain tumors, and ischemia.
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/26/2017 11:19:51 AM
Research Description
The study of central nervous system structure and function with magnetic resonance. In particular, mapping of brain structural connectivity using diffusion-weighted magnetic resonance imaging methods and the mapping of functional connectivity with function magnetic resonance imaging.

Mark Q. Martindale, Ph.D.

Department:
Whitney Laboratories
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/22/2015
Research Description
Director of the Whitney Laboratory for Marine Bioscience and renowned scientist. His research focus is aimed at elucidating the cellular and molecular basis for the evolution of cell-type complexity.
Department:
Physiological Sciences
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/29/2017 11:39:20 AM
Research Description
toxicology, sex steroids, neuroendocrinology, gamma-aminobutyric acid, transcriptomics, proteomics, reproduction
Department:
Anesthesiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017 4:20:16 PM
Research Description
Mechanisms of long-term central and systemic abnormalities induced by neonatal exposure to general anesthesia. Mechanisms underlying the causes of epilepsy in phenylketonuria (PKU).

Mathews, Carol M.D.

Department:
Psychiatry
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/15/2017
Research Description
Our group studies how genes, environment, and culture interact to influence human emotion and behavior. In particular, we focus on how these factors affect the development and expression of neuropsychiatric syndromes, including anxiety, resilience, ADHD, OCD, compulsive hoarding, and tic disorders. Approaches include neuropsychological, electrophysiological, and physiological approaches, as well as functional neuroimaging.
Department:
Neuroscience
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/26/2017
Research Description
Oscillations are prominent in all realms of the physical and biological world. Clocks tick, fire flies flash and neurons of the brain ‘fire’ action potentials. While it is known that two clocks on a wall will synchronize their pendulums and specific species of fire flies will phase lock their flashes, the basic mechanisms of how large populations of neurons interact in a coordinated manner to enable a rich repertoire of adaptive behaviors is relatively unknown. Specifically, we have a limited understanding on how neurons self-organize their activity to produce the synchrony that is needed to transfer information across large-scale neural networks. Moreover, even less is known regarding how information is transformed and updated as it propagates across the brain. Theoretically, it is the oscillatory rhythms of the brain, along with the synaptic architecture, that allow neurons to transiently synchronize and desynchronize their activity, optimizing nimble computations at the “speed of thought”. Fortunately, we have reached a technological threshold that has permitted the testing of theoretical models on large amounts of neural data. Therefore, my research seeks to understand how the brain, a densely interconnected set of individual neurons, rapidly translates environmental information into complex representations in support of cognitive function. In order to achieve these goals, my collaborators and I have embarked on a unique research trajectory that will allow us to test the hypotheses of complex network activity using both a bottom-up approach, inspired by computational models, and a top-down approach, re-evaluating our data in the perspective of non-linear physics. It is our expectation that, by adopting an integrative approach that bridges disciplines, we can learn how the small actions of single neurons, connected in a network can bring about the emergence of sophisticated dynamics that support behavior and higher cognitive function. Moreover, by examining neural processing on multiple scales, from small groups of isolated cells to the population dynamics of entire brain regions, we believe that we will find a common etiology of how coordinated activity emerges that can be extended into the larger field of complexity.” “We also have a research track investigating the changes in neuronal dynamics behind age-related decline in memory and cognition. Along with my collaborators in McKnight Brain Institute in the Age-Related Memory Loss group, we seek to find therapeutic interventions that maximize longevity and neuronal processing in hopes of maintaining independence in the elderly population.
Department:
Neurology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017 1:01:51 PM
Research Description
My research focuses on understanding the pathological mechanisms of Parkinson disease and related disorders, and in particular the role that abnormal protein accumulation, such alpha synuclein, plays in these disorders.
Department:
Neuroscience
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
6/26/2017
Research Description
The McIntyre Lab is broadly interested in the molecular mechanisms that underlie olfactory function. We study both the sensory neurons in the nasal cavity that detect odors in the environment as well as the neurons in the olfactory bulb that begin the neural processing of this information. The lab currently has several ongoing projects. First, we are applying gene therapy approaches to correct congenital defects in the sense of smell. Currently we are focused on mutations affecting ion channel function. We are developing methods to delivery and re-express functional copies of these channels to the olfactory epithelium to restore olfactory function. To evaluate the effectiveness of these therapies we used immunofluorescence, calcium imaging, electrophysiology and behavioral experiments. In the olfactory bulb, we are studying how physiological conditions affects odor processing. Input into the olfactory bulb from higher regions of the brain are known to modulate how neurons in the bulb respond to odors, making them more or less responsive. We are investigating neuromodulators involved in hunger/satiety signaling and those that change with aging. Our work focuses on several GPCRs involved in these signaling pathways that localize to the primary cilia that project from neuronal cell bodies. Cilia are critical for cellular function, and disruptions of cilia function can lead to numerous disease phenotypes. The lab is working to further understand the role of cilia in integrating a variety of signals and the modulation of neuronal processes. To achieve these goals, we have developed several new mouse models to look at cell specific ablation of cilia and immunofluorescence and confocal microscopy, calcium imaging, electrophysiology, molecular biology and behavior.
Department:
Physical Therapy
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/26/2017
Research Description
We focus on cellular mechanisms of spinal respiratory (and non-respiratory) motor plasticity following intermittent exposure to low oxygen (intermittent hypoxia). We investigate mechanisms at the cellular through whole animal levels, and actively explore the ability to harness intermittent hypoxia as a treatment to improve respiratory and non-respiratory motor function in rodent models of chronic spinal injury and ALS. In multiple collaborations, we also test the potential of intermittent hypoxia to enhance function in normal humans, and to treat those with chronic disease or spinal injury.
Department:
Neurosurgery
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/22/2015
Research Description
Department:
Psychiatry
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2017 3:43:34 PM
Research Description
Behavioral effects of drug of abuse used recreationally (e.g. cocaine) and medicinally (e.g. opioid painkillers) in rats.
Department:
Whitney Laboratories
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
7/6/2017 11:50:20 AM
Research Description
Genomic Bases of Memory and Neuronal Evolution. Our laboratory works to characterize basic mechanisms underlying the design of nervous systems and evolution of neuronal signaling mechanisms. The major questions are: (1) why are individual neurons so different? (2) How do learning and memory store in neuronal genomes and neural circuits? (3) How to restore memories? (4) How to make a neuron and a brain?
Department:
Pharmacology & Therapeutics
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017
Research Description
We use molecular biological, anatomical and behavioral approaches to understand how receptors and signal transduction cascades contribute to chemosensory detection in olfactory, taste, and endocrine systems.
Department:
Orthodontics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/3/2016 9:53:20 AM
Research Description
Neurophysiology of pain; inflammation and neuropathic pain; chronic pain mechanisms; translational research for chronic pain.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/26/2017
Research Description
Our research focuses on understanding the underlying molecular mechanisms controlling gene expression in the inflammatory response and in the etiology of Type 1 Diabetes.
Department:
Psychiatry
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/12/2017 12:22:31 PM
Research Description
Neurocognitive processes associated with acute and chronic substance use, effects of aging, gender differences
Department:
Neuroscience
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/26/2017 3:02:22 PM
Research Description
Studies on the cellular and molecular bases for inherited peripheral neuropathies and approaches to attenuate the accumulation of misfolded proteins within cells. Schwann cell biology, myelin formation, small molecule therapies and dietary approaches
Department:
Neurology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/12/2017 2:50:57 PM
Research Description
Dr. Okun’s laboratory has focused on identifying the physiological brain signature patterns for tics and other movement disorders, and also has been focused on the development of neurotechnology for a closed loop solution to tic disorders. Dr. Okun’s research efforts have also been focused on the motor and non-motor aspects of deep brain stimulation as applied to basal ganglia disorders.
Department:
Biomedical Engineering
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/26/2017 12:45:56 PM
Research Description
Studies how stem cell strategies could be used to repair the brain. We use the hippocampus as a model to understand how make the brain receptive to neuron addition because the hippocampus adds new neurons throughout life in all mammals, including humans
Department:
Biomedical Engineering
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2017
Research Description
Neural engineering. Sensory repair and prostheses . Brain-machine interfaces. Sensation induced by activation of neural tissue. Neural coding and plasticity.
Department:
Electrical and Computer Engineering
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
7/6/2017
Research Description
Sensorimotor Integration, Cognitive Skill Learning, Systems & Computational Neuroscience, Clinically Viable Brain Machine Interfaces
Department:
Pharmacology & Therapeutics
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/15/2017
Research Description
Physiology, pharmacology, and biophysics of neurotransmitter receptors especially the function of nicotinic acetylcholine receptors in the brain. We are additionally interested in addiction and the development of drug cessation therapies for smokers and people addicted to the use of betel quid.
Department:
Physiology & Functional Genomics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/22/2015
Research Description
Signal transduction mechanism of angiotensin regulation of norepinephrine neuromodulation in the brain; antisense targating of renin/angiotensin to control cardiovascular diseases; gene therapy, neurobiology, brain cytokines in neurogenic hypertension.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
6/26/2017 11:27:22 AM
Research Description
Uses human genetics studies to define the molecular causes of neurological and neuromuscular disease and animal models to understand how disease-causing mutations affect neuronal function.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2017
Research Description
Regeneration in CNS and PNS with emphasis on neural tissue transplantation and spinal cord injury and repair; cell biology of neurons and glia in the developing and injured spinal cord.
Department:
Neurosurgery
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/15/2017 3:42:28 PM
Research Description
Characterization and manipulation of adult neural stem cells.
Department:
Neurology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/26/2017
Research Description
My laboratory applies a variety of techniques to study the molecular pathways associated with several neurodegenerative diseases and to discover potential therapeutic targets. To do so, we use a multidisciplinary approach combining Drosophila genetics, neuroscience, molecular biology, biochemistry and optogenetic technologies.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2017 12:34:09 PM
Research Description
Cellular and molecular mechanisms underlying normal and pathogenetic development of the cerebral cortex.
Department:
Neurosurgery
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/12/2017
Research Description
Current interests include developing innovative immunotherapeutics for pediatric tumors and invasive central nervous system malignancies. Dr. Sayour’s main focus is deeply rooted in harnessing the immune system to eradicate pediatric cancers. He has received several extramural grants to support his research efforts including the Hyundai Hope on Wheels Hope Award, ASPHO Young Investigator Award, and the American Brain Tumor Association Discovery Award. Dr. Sayour has been involved in translating bench work into clinical trials governing the development of dendritic cell vaccines with adoptively transferred cytotoxic T cells against recurrent medulloblastoma. He has also started an integrative pediatric immunotherapy working group at UF that includes surgeons, clinicians, veterinarians, and pre-clinical scientists working to advance novel directed therapeutics against refractory malignancies. Their goals are to identify novel antigen targets and construct robust immunotherapeutic treatments against these malignancies.
Department:
Physiology & Functional Genomics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/1/2016 12:31:28 PM
Research Description
Effects of stress and chronic elevations in glucocorticoids on central nervous system control of cardiovascular function.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2017 3:47:29 PM
Research Description
Inherited Photoreceptor disease, viral vector-based gene therapy, and circadian biology. My current focus is online and hybrid approaches to graduate education.
Department:
Psychiatry
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/12/2017 12:34:53 PM
Research Description
Behavioral and neurobiological basis of decision-making, in relation to addiction and other psychiatric conditions. We employ a range of techniques, including behavioral pharmacology, optogenetics, and in vivo electrophysiology.
Department:
Ophthalmology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017 12:18:31 PM
Research Description
Molecular biology and biochemistry of vision in vertebrates and invertebrates.
Department:
Community Dentistry and Behavioral Science
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/1/2015 4:09:11 PM
Research Description
Psychophysical measurement with an emphasis on taste and other oral sensations. Associations between the sensory properties of foods and health.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2017 3:40:34 PM
Research Description
Neuroimmunology and experimental neuropathology. Neurobiology of microglial cells.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/15/2017 11:19:18 AM
Research Description
Mouse models for neurological disease;RNA processing, transport and turnover; molecular mechanisms of mammalian development and aging
Department:
Neurosurgery
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
4/11/2016
Research Description
My research program is focused understanding the mechanism of cancer metastasis and dormancy. The epithelial mesenchymal transition (EMT) is now suggested to play an important role in the initial invasion during cancer metastasis. However, direct in vivo evidence is currently lacking. Our lab is interested in understanding how cancer EMT contributes to cancer metastasis, and if so whether it also regulates cancer dormancy, a phenomenon in which micrometastatic disease is present in multiple organs but clinically undetectable.
Department:
Pharmacology & Therapeutics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2017 12:44:11 PM
Research Description
Oxidative stress, Aging and central regulation of blood pressure.
Department:
Physiological Sciences
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/12/2017 12:01:59 PM
Research Description
Drug use in food producing animals; pharmacokinetic modelling
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017 4:37:29 PM
Research Description
The Vitriol lab uses live cell and super resolution microscopy to study the actin cytoskeleton in cell motility, neural development, and neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS).

Aparna Ashutosh Wagle Shukla

Department:
Neurology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/29/2017
Research Description
Physiology of Movement disorders (dystonia, tremor, Parkinson's disease)
Department:
Psychiatry
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/12/2017
Research Description
Protease and kinase over-activation in central nervous system diseases; Tauopathy/proteinopathy, biomarkers, proteomics for traumatic brain injury, spinal cord injury, substance abuse, exosome and microRNA pathways
Department:
Neurology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/26/2017
Research Description
Dr. Williamson has completed a clinical fellowship in neuropsychology and research fellowship in neuroscience. His research includes central and peripheral nervous system interactions in regulating behavior including cognition and emotion. He has active projects in cardiovascular disease contributions to cognitive impairment, traumatic brain injury and emotional dysregulation, and the application of noninvasive nerve stimulation technologies to modify cognitive and emotional performance.
Department:
Physiology & Functional Genomics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2017
Research Description
Fetal neuroendocrine development and cardiovascular physiology.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
7/12/2017
Research Description
Cognitive function declines as we age. As our thinking and memory skills decline, the rate of functional dependence, mortality, and acute illness requiring hospitalization increases. A variety of methods have been proposed to counteract cognitive aging (e.g., cognitive training). Unfortunately, these techniques have limited degrees of success and transfer to everyday life. My work demonstrates that combining treatments like cognitive training with non-invasive brain stimulation (tDCS, TMS, tACS) facilitates neuroplastic response of brain tissue, improves cognitive abilities (specifically working memory, attention, and speed of processing), and leads to long-term improvement. In combination with modern multimodal neuroimaging and electrophysiology recording, this work not only identifies mechanisms underlying improvement, but also provides information important for further optimizing treatment effectiveness. Dr. Woods is PI of the largest NIH/NIA-funded Phase III tDCS trial, the ACT study. The ACT study investigates benefits of tDCS paired with cognitive training for cognitive and brain function and slowing onset of dementia in older adults.
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017 2:02:24 PM
Research Description
electrophysiological property of non-excitable cells; intercellular & intracellular calcium signaling pathways; functional role of purinergic signaling; functional role of P2X & P2Y receptors in SGK1-regulated ion transport in the kidney.
Department:
Medicine-Jax
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/22/2015
Research Description
Role of H+ V-ATPase and novel secondary transporter Na+ or K+/H+ antiporter
Department:
Pediatrics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
7/24/2015
Research Description
Clinical genetics and cytogenetics, neurodevelopmental diseases.

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