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Department:
Oral Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/26/2017
Research Description
Bacteria-Host Interactions, Systemic infections, Oral infections, Intracellular Bacteria, Biofilms, bacterial genetics and physiology
Department:
Oral Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/12/2017
Research Description
My research area is to elucidate the regulatory pathways of oral bacteria, with particular focus on biofilm formation and stress tolerance that can modulate the virulence of oral bacteria and enhance the pathogenic potential of oral biofilms. Stemming from the original AtlA work, another major research area is to investigate the molecular basis for regulation of autolysis of S. mutans by gene products that have major effects on traits related to virulence. This research focuses on the characterization of a pair of dicistronic operons, lrg and cid-like, that significantly affected autolysis and biofilm formation by S. mutans.
Department:
Infectious Diseases and Pathology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2017 9:24:58 AM
Research Description
Cellular and molecular bases of host-parasite interactions; immunology of hemoparasitic diseases.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2017 1:10:58 PM
Research Description
Natural history of Type 1 Diabetes; cellular immunology, clinical trials for disease prevention and reversal; beta cell regeneration; pancreatic pathology; microbiome; translational medicine.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/26/2017 7:44:54 AM
Research Description
Her research interest is mechanisms of immune regulation and their alterations in autoimmune diseases, including multiple sclerosis and inflammatory bowel disease, as well as in infectious diseases, including influenza and listeriosis. Her work has an important impact in development of therapies for the control of autoimmune diseases.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
7/6/2017
Research Description
Functional genomics; gene expression profiling using DNA microarrays to understand phenotype.Developing gene expression classifiers of prognostic value.
Department:
Infectious Diseases and Pathology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2017 1:48:15 PM
Research Description
Molecular biology of parasitic and ehrlichial diseases of cattle; development of recombinant vaccines and diagnostic tests, molecular mechanism of pathogenesis.
Department:
Pediatrics
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
10/25/2017
Research Description
Sumita Bhaduri-McIntosh is a physician-scientist whose research bridges the fields of Virology, Oncology and Immunology. Research in the Bhaduri laboratory is focused on discovering fundamental biological pathways and understanding cancer development and progression by studying the interaction between Epstein-Barr virus (EBV; a cancer-causing herpesvirus) and its host, the B cell, by investigating two main areas: 1) investigating how EBV subverts anti-pathogen and anti-cancer barriers such as immune responses and the DNA-damage response (DDR) to drive B cell proliferation and transformation, and 2) identifying host factors that determine susceptibility of EBV-infected B cells to lytic activation, a process important for herpesvirus pathology and persistence in humans, and for lymphomagenesis.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017 11:01:32 AM
Research Description
Molecular pathogenesis of the herpesviruses; role of long non-coding RNAs and miRNAs on latency and reactivation; development of novel therapeutics to disrupt HSV latency and block recurrent disease.
Department:
Oral Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/11/2015 4:52:32 PM
Research Description
Streptococcal protein translocation; stress responses; membrane biogenesis; biofilm formation; bacterial adhesion; functional amyloid formation; host/pathogen interactions; immunomodulation by monoclonal antibodies; structure/function of streptococcal sur
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/10/2016
Research Description
The goal of our work is to understand how misfolded alpha-1-antitrypsin causes cellular injury in liver and innate immune cells and to develop rational therapies to modulate this injury. To accomplish this goal we use cellular and animal models and transl
Department:
Institute for Therapeutic Innovation
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/26/2017 12:17:44 PM
Research Description
My research focuses on designing optimized therapeutic regimens for antiviral compounds active against viruses that pose a significant threat to global public health including influenza virus, influenza virus, dengue virus, chikungunya virus, hepatitis C virus, and HIV.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017 12:16:39 PM
Research Description
Regulation of immunity & autoimmunity; prediction, intervention, and treatment for type 1 diabetes. The lab is focused on the mechanisms by which regulatory T cells maintain peripheral immune tolerance in the context of type 1 diabetes.
Department:
Oral Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2017 11:50:09 AM
Research Description
Environmental regulation of bacterial gene expression and virulence.
Department:
Pediatrics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2017
Research Description
Cardiovascular gene therapy; adeno-associated viral vectors.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
5/31/2016
Research Description
Characterize the immune suppressor mehanisms involved in the develeopment of HCC in the background of cirrhosis to identify novel targets that can lead to development of new immune activating strategies and/or prognostic and predictive immune biomarkers.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017 12:07:02 PM
Research Description
My laboratory is examining mechanisms for loss of human beta cells in type 1 diabetes and ways to regenerate functional beta cell mass. Studies are conducted using human biospecimens, isolated islets, and beta cell lines with experiments focused on the role of neurotransmitters and neurohormones in beta cell regeneration. Techniques include IHC, ISH, laser microdissection, microscopy (brightfield, fluorescence, confocal), in vitro cell proliferation/apoptosis, transfection, RNA and RNAseq analysis, Western blot, and other molecular biology techniques.
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/12/2017
Research Description
host-pathogen interactions; adaptive immune responses of chronic and tropical diseases.
Department:
Oral & Maxillofacial Surgery and Oral Diagn Sci
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017 9:40:44 AM
Research Description
Pathogenesis of autoimmune Sjogren's syndrome The roles of miRNA in regulating innate immunity of Sjogren’s syndrome Development of diagnostic/therapeutic strategies for Sjogren's syndrome Radiation-induced xerostomia in head and neck cancer patients Stem cell research for salivary gland regeneration
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
9/7/2017
Research Description
Srikar Chamala, Ph.D., leads the clinical bioinformatics and biomedical informatics efforts at the University of Florida Health Pathology Laboratories Molecular & Genomic Pathology Laboratory in developing next-generation sequencing clinical assays and data management for precision medicine. He also performs research in understating genetic basis for cancer and type 1 diabetes, using sequencing and array-based genomics technologies. Dr. Chamala’s research in genomics and bioinformatics has been published in high-impact journals, including Science, Nature, and Genome Biology, and he has also been highlighted by news outlets across the globe.
Department:
Oral Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017 1:09:57 PM
Research Description
The current research projects are 1) studies of microRNAs in the regulation of toll-like receptor signaling pathways in innate immune response and their relationship to autoimmune diseases, including rheumatoid arthritis and systemic lupus erythematosus and periodontal disease; 2) oral cancer pathogenesis and development of immunotherapy for these cancers.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/6/2017 12:04:53 PM
Research Description
Development of novel gene transfer tools, small animal models for the study of HIV and cancer, vaccines and immuno-therapeutic strategies for these diseases.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2016 7:47:33 AM
Research Description
Translational research Cell-based therapy for type 1 diabetes Dr. Clare-Salzler is a JDRF, NIH-funded basic and clinical scientist investigating the autoimmune process that causes Type 1 Diabetes (T1D). The major focus of the laboratory is on the role o
Department:
Infectious Diseases and Pathology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
7/24/2017
Research Description
Mycobacterium tuberculosis, the causative agent of tuberculosis. Investigate how these bacteria survive and grow within human cells to cause TB. We are using this knowledge to develop a safe, effective vaccine to protect people against infection.
Department:
Pediatrics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/26/2017
Research Description
My current research as an Assistant Professor in the Department of Pediatrics focuses on understanding the contribution of neurological impairment in neuromuscular disorders by combining my expertise in clinical assessment and novel gene therapy approaches to restore muscular and the neurological impairments in neuromuscular disease.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
7/6/2017
Research Description
Innate and acquired immune mechanisms in the pathogenesis of kidney disease: chronic allograft mephropathy, diabetes and lupus nephritis.
Department:
Infectious Diseases and Pathology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/26/2017
Research Description
Department:
Infectious Diseases and Pathology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/21/2017 11:44:55 AM
Research Description
Interests of the Dame lab include emerging and re-emerging pathogens of animals and man; molecular biology of the malaria parasite; drug and vaccine target identification in Plasmodium falciparum. Current projects include: Refinement of ultrasensitive test for malaria infection Selective pressures exerted on the malaria parasite by novel mosquito vectors
Department:
Oral Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/26/2017 9:20:45 AM
Research Description
The primary goal of the human microbiome project is to increase our understanding of the structure and function of our microbiota and to elucidate their role in health and predisposition to disease. One of the best-understood human-associated microbial systems is the oral microbiome. The Davey lab uses a combination of molecular genetics, bacterial physiology, and biochemical techniques to study the oral microbiome. In particular, we are focused on the regulator mechanisms (environmental and interspecies signals) that control the pathogenic state of the oral anaerobe, Porphyromonas gingivalis.
Department:
Oral Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/12/2017 9:47:41 AM
Research Description
The research in my laboratory focuses on the role of host defense peptides in the defense against infectious diseases at mucosal surfaces. Defensins and cathelicidins are two classes of peptides that play important roles in innate immune defenses against microbial pathogens. They exhibit broad-spectrum antimicrobial activity, and also modulate the innate immune system. We are studying them in two different ways: First, we are examining how their genes are regulated in the lung and in the oral cavity, by factors such as vitamin D and cytokines, to develop new ways of treating and preventing infectious diseases. This utilizes both molecular biology approaches with cultured cells as well as in vivo infection models. Second, we are working with a company to develop novel molecules based on these naturally occurring peptides, to treat and prevent oral and systemic microbial infections. This involves quantifying the in vitro activity of these compounds against microbial pathogens, as well as testing then in mouse models of infection.
Department:
Ophthalmology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/27/2017
Research Description
Dr. Dinculescu received her Ph.D. in Biochemistry from University of Florida in 2002. Her research is focused on understanding the molecular mechanisms in several retinal degeneration disorders, including Usher syndrome. The ultimate goal is to develop therapeutic strategies to prevent the loss of sight caused by these disorders. Usher syndrome type III (USH3A), an autosomal recessive disorder, is caused by mutations in Clarin-1 (CLRN1) protein, leading to combined vision and hearing loss. The main goal of this project is to understand the function of CLRN1 in the retina, identify its binding partners, and its cellular localization pattern. This information will be used to develop a rational treatment for the USH3A disorder. She is also interested in protein aggregation mechanisms leading to the formation of extracellular deposits associated with vision loss in age-related macular degeneration, a major cause of blindness in the elderly population.
Department:
Vet Med- Research
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/26/2017
Research Description
Systems Biology of Vector Borne Disease Transmission Dynamics: Multi-OMICS approaches to dissecting fundamental host-pathogen interactions. Discovery of novel interventions in the fight against malaria requires a pioneering approach to examine cell-cell interactions among the transmission stages of the parasite (i.e., sporozoite and ookinete) and their respective mammalian or mosquito host cells.
Department:
Animal Sciences
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017 12:58:17 PM
Research Description
Strategies to enhance the immunity of domestic animals and the transfer of the resulting discoveries for the improvement of human health.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
6/26/2017
Research Description
Infectious Diseases, mathematical modeling, chemotherapy, pharmacokinetics, pharmacodynamics, bacteria, virus, and fungi
Department:
Pediatrics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
7/24/2017 1:08:37 PM
Research Description
Effect of immunosuppression on anti-GAA antibody development in patients with Pompe disease, clinical trial studies as part of CARRA (Childhood Arthritis and Rheumatology Research Alliance)

Kevin P. Fennelly, MD

Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/22/2015
Research Description
Assessing infectiousness of tuberculosis and other infections via cough aerosols. ; TB diagnostics
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
5/23/2016
Research Description
Molecular biology and genetics of RNA virus replication.
Department:
Oral Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/15/2017
Research Description
Molecular mechanisms of periodontal diseases. Oral microbiome-host interactions Metatranscriptome of the oral microbiome in health and disease
Department:
Oral Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/12/2017
Research Description
Research in my lab is focused in areas of host-pathogen interaction geared toward developing a better understanding of the host mechanisms and bacterial structures important in infection-elicited inflammation. To accomplish this we use a variety of approaches including molecular, cellular, immunological, and animal modeling to develop a synthetic understanding of relevant systems. Work has centered on identification of host cell receptors engaged by key bacterial structures/adhesins, and the subsequent signaling pathways activated which lead to immune activation, with the goal to harness those factors in a manner that can lead to re-establishment of normal tissue homeostasis. Current investigative lines utilize the bacterium Porphyromonas gingivalis as a model oral organism to study key facets of anaerobic bacterial infection and contribution of bacterial structures such as capsular polysaccharides in the development of inflammation and oral bone loss. A particular area of interest is identification of molecular targets and pathways that could serve as novel points for therapeutic intervention to augment available treatments aimed to limit periodontal tissue destruction. In addition to the work focusing on the pathogenesis of oral disease, our group engaged in collaborative studies that have been seminal in identifying associations of oral bacterial infection with cardiovascular disease. Work in this area provides experimental evidence that P. gingivalis is a potential risk factor for atherosclerosis, and that this infection-elicited acceleration can be prevented through immunization. The underlying mechanisms of this association are not well defined. More recently we have become interested in nuclear hormone receptors including liver x receptors and peroxisome proliferator-activated receptors in the development of bacteria-elicited inflammation, and contribution of inflammatory cues at sites of infection in the pathogenesis of periodontal disease. Furthermore, collaborative studies have begun to explore P. gingivalis interactions with adipocytes, as well as integrative studies to investigate aspects of P. gingivalis / HIV co-infection.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
1/19/2017 1:06:57 PM
Research Description
My clinical practice is focused on inflammatory bowel disease, Crohn’s and ulcerative colitis, and on allergic gastrointestinal disorders, eosinophilic GI disorders and GI mast cell disorders. I have approximately 2000 patient visits per year which is important for both my clinical and bench research. My bench research focuses on innate immune mechanisms of gut inflammation. Specifically, we study innate lymphoid cell (ILC) plasticity in inflammation and infection, ILC and T cell interactions in inflammation, and mast cell behavior in the GI tract.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017 12:53:49 PM
Research Description
We use molecular genetics and genomics coupled with animal models to examine how a normal intestinal bacterium, Oxalobacter formigenes, helps prevent kidney stones.
Department:
Pediatrics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/19/2017
Research Description
Prevention and Reversal of Type 1 diabetes
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2016
Research Description
My area of interest is social determinants of health, impact of stress in childhood on health outcomes, perinatal outcomes.
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017
Research Description
Development of anti-infective countermeasures for bacterial infections of bio-warfare or bio-terrorism potential. Development of aerosol infection models.
Department:
Pediatrics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/26/2017 11:45:40 AM
Research Description
Gene therapy for the inherited bleeding disorder hemophilia; immunology of in vivo gene transfer; tolerance induction to therapeutic proteins.
Department:
Psychiatry
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/29/2016
Research Description
1. Gene therapy using recombinant adeno-associated virus-based vectors for the treatment of brain and thyroid disorders 2. Parvovirus-host interactions
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/7/2017
Research Description
Innate defense mechanisms against resistant Gram-negative bacteria Influenza and emerging infectious diseases
Department:
Medicine
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017
Research Description
1) Mucosal vaccines development. 2) Pneumococcal infection. 3) Human genetic variants.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017 1:37:13 PM
Research Description
Molecular mechanisms of host-pathogen interactions; virulence mechanism of Pseudomonas aeruginosa infection and development of antimicrobial strategies; Cellular reprogramming and genome editing
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
7/24/2017
Research Description
Microbial pathogenesis, antibiotic resistance, microbial genetics, molecular epidemiology, microbial ecology.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
6/11/2015 4:54:16 PM
Research Description
Pathogenesis of noroviruses, innate immune responses to norovirus infection, and molecular mechanisms of norovirus replication. Mucosal immunity to, and pathogenesis, of murine norovirus infection.
Department:
Biomedical Engineering
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
6/1/2016
Research Description
The Biomaterial Immuno-Engineering Lab focuses on the engineering of biomaterial-cell interactions, and targeted controlled release of immune modulating factors in order to direct immune cell function.
Department:
Microbiology & Cell Science
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/6/2017 12:21:09 PM
Research Description
Our overall goal is to elucidate the mechanisms by which Leishmania parasites persist in infected hosts. Specifically, we investigate how the parasite's niche within macrophages is formed. In addition, we seek to identify the virulence factors that Leishmania elaborate
Department:
Urology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/15/2017 10:44:30 AM
Research Description
Our research is focused on tumor immunology, including immunotherapy and mechanisms of immune escape in urologic cancers (prostate, kidney, bladder) in both clinical and experimental settings.
Department:
Periodontology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/15/2017 9:47:01 AM
Research Description
Major interests are to examine the role of major periodontal pathogens causal association with systemic diseases including atherosclerosis, rheumatoid arthritis and Alzheimer’s disease
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/27/2017
Research Description
Dr. Lauzardo is a medical doctor who is an associate professor in the department of medicine. He serves as chief of the division of infectious diseases and global medicine. He is an expert on tuberculosis and refugee health issues. Dr. Lauzardo’s research is focused on the molecular epidemiology of tuberculosis and tuberculosis transmission.
Department:
Oral Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/26/2017
Research Description
My Laboratory investigates the molecular factors that promote virulence in the opportunistic Gram-positive pathogens Streptococcus mutans and Enterococcus faecalis. S. mutans is a major pathogen in dental caries and a leading causative agent of infective endocarditis. In S. mutans, our current efforts focus on the characterization of the Spx global regulator, and its role in controlling stress responses and biofilm formation. The second S. mutans project, in collaboration with Dr. Jacqueline Abranches, focuses on the characterization of a collagen binding protein responsible for intracellular invasion of human heart and oral tissues, a trait that is potentially linked to increased virulence, recurrent infection and chronic inflammation. The characterization of stress responses is also the theme of our research with E. faecalis, a leading cause of hospital-acquired infections. In this project, we are investigating the interplay between the stringent response, a major bacterial stress response mechanism for adaptation to changing environments, with other prominent stress regulators and how these interactions influence the ability of E. feacalis to survive under adverse conditions.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2017 12:06:25 PM
Research Description
Dr. Lewin's current research involves the development of gene and pharmacological therapies for neurodegenerative diseases of the retina and the central nervous system. The group has developed a mouse model of Age Related Macular Degeneration, a common blinding disease of the elderly.

Chen Ling, Ph.D.

Department:
Pediatrics
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/19/2017
Research Description
Dr. Ling's research focused on gene therapy of inherited diseases, such as hemophilia and sickle cell disease. Specifically, Dr. Ling studies the interaction between adeno-associated virus and its target cells, such as hepatocytes and hematopoietic stem cells.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
7/6/2017 3:24:12 PM
Research Description
My group uses sophisticated in vitro and murine infection models to develop regimens for investigational and marketed antibiotics that maximize the killing of bacterial “superbugs” and prevent other bacteria from becoming “superbugs.” The interaction of the immune system with antibiotic(s) to kill microbes is also evaluated.
Department:
Pediatrics
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/12/2017
Research Description
The research in my lab is focus on developing new therapies of lysosomal storage diseases (LSDs) based on the understanding of molecular mechanisms of the pathogenesis of these diseases. These inherited metabolic conditions are caused by defects in a wide spectrum of lysosomal and a few non-lysosomal proteins resulting in accumulation of undigested substrates, resulting in dysfunction of lysosomal/endosomal system. The almost 60 different LSDs are individually rare genetic conditions, but, collectively, the incidence is approximately 1/2,000-3,000 live births. Since lysosomal/endosomal system is essential for cell homeostasis, this “inborn organelle disorders” results in multi-systemic diseases, and predominantly affecting the brain. The study LSDs allowed the discovery of several biological processes including the discovery of mannose-6-phosphate targeting system and currently gives insights into neurodegenerative mechanism in Alzheimer and Parkinson’s diseases. In LSDs, the development of clinical symptoms usually correlates with a level of residual deficient enzyme activity. In patients with late onset forms of LSDs, a residual lysosomal activity is a result of missense mutations, which partially preserves catalytic enzyme function but mostly impairs the early folding process in the ER. These mutant lysosomal enzymes do not reach its appropriate conformation, and subsequently are directed to ER-associate degradation (ERAD) pathway, and are ultimately degraded by the ubiquitin-proteosome system. In this context, small molecule therapeutics are an attractive approach to treat LSDs. Enzyme-enhancement agents, including pharmacological chaperones (PC), are small molecules which are able to assist a mutant misfolded protein to achieve a native-like conformation in the endoplasmic reticulum (ER), allowing it to escape the ERAD pathway, and reach the lysosome. An advantage of this approach is that small molecules are much more likely to cross the blood brain barrier and reach neuronal cells, which are dramatically affected in LSDs. In addition, principles learned in treating one type of LSD can be applied not only to other LSDs, but also to other misconformation protein diseases, which is also feature of common neurodegenerative conditions.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
7/24/2017 10:15:56 AM
Research Description
Genetics of resistance to autoimmune diabetes; oxidative burden of the beta cell.
Department:
Environmental Health
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017 12:22:13 PM
Research Description
Pathogenic mechanisms of Shigella and Chlamydia Evolution and emergence of Shiga toxin-producing Shigella flexneri Cell wall metabolism and cell division processes of Chlamydia spp. Surveillance of non-HIV sexually transmitted infections in Haiti Laboratory capacity building
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2017 1:48:54 PM
Research Description
Genetics of susceptibility to autoimmune disease, vitiligo, education research.
Department:
Periodontology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/3/2016
Research Description
We focus primarily on osteoimmunology, which is the study of interactions between immune cells, immune mediators, and immune signaling in skeletal biology. In particular, we study the differentiation of bone-resorbing osteoclast cells in response to bone
Department:
Pediatrics
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
10/25/2017
Research Description
Advanced molecular biology and bioinformatics are combined with traditional microbiology to reveal connections between infectious agents and diseases of unknown etiology or emerging epidemiology. Lab emphasis is on detection and characterization of potential pathogens and investigating host microbial interactions to reveal underlying mechanisms of disease as well as targets for diagnosis or intervention. Broad areas of study include microbial, in particular viral, discovery in the context of clinical disease, at the human animal/vector interface, and in the contexts of immunocompromise or cancer.
Department:
Infectious Diseases and Pathology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
5/24/2016 11:07:30 AM
Research Description
Retrovirus vector for gene transfer based on foamy virus. Comparative and experimental pathology.
Department:
Neurosurgery
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
7/20/2017
Research Description
Immunotherapy of adult and pediatric brain tumors. Mechanisms of resistance in brain tumors to immunologic rejection. Combinatorial therapeutics involving chemotherapy, radiation, and immunotherapy
Department:
Infectious Diseases and Pathology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/26/2017 2:14:05 PM
Research Description
Intestinal disorders (IBD, colon cancer) and oral vaccine delivery
Department:
Surgery
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
7/24/2017 12:53:08 PM
Research Description
The laboratory focuses on the innate and adaptive immune response to severe critical illness, including trauma, and surgical sepsis. Working with cell culture, animal models and clinical observation and interventional trials, the laboratory focuses on studying myelopoiesis, myeloid cell development, MDSCs and mature dendritic cell responses to severe trauma, severe sepsis, chronic critical illness and the PICS syndrome.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2017 1:55:29 PM
Research Description
Genetic analysis of systemic lupus erythematosus (SLE) susceptibility using mouse models, immune metabolism and use of metabolic inhibitors to treat lupus Microbiome and lupus
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/22/2015
Research Description
Molecular epidemiology and transmission modeling of Vibrio cholerae in Haiti and Bangladesh.
Department:
Oral Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
7/24/2017
Research Description
My main research projects focus on investigating the relationship between oral alkali production from arginine and dental caries experience in children and adults.
Department:
Oral Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017
Research Description
I. Elucidating the pathogenesis of Sjögren’s syndrome (SjS). It is an autoimmune disease that involves the destruction/dysfunction of the salivary glands and lacrimal glands leading to dry mouth and dry eye disease. Several aspects of the disease are intriguing which permits me to apply novel approaches in both understanding the pathogenesis and transitioning my basic research findings to the clinical application: a) SjS predominantly affects post-menopausal women with a gender predilection of 10:1 women to men ratio; b) SjS patients have a diminishing quality of life as the disease progresses and affects multiple organ systems; c) 4-6% of patients develop low-grade B cell lymphomas, some of which eventually become high-grade and life-threatening; and d) The pathogenesis is triggered by yet undefined genetic susceptibility and unknown environmental factors. Thus, SjS offers multiple interesting facets for studying the immuno-pathophysiological processes of the autoimmune disease and a tremendous challenge in designing effective diagnostic markers and therapeutic treatments for patients. At the present, my research focuses specifically on three aspects of SjS etiology: 1. Deciphering the role of regulatory B and T cells in the development of SjS, specifically focusing on the designing vaccines to induce functional regulatory cells 2. Examining the immunological function of T helper (Th)-17 cells and its role in the sexual dimorphism 3. Identifying new biomarkers and developing diagnostic platform for early detection of SjS using single-cell technology II. Developing therapeutic antibodies to protect against Zika and Dengue viruses using single-cell technology. Zika virus (ZIKV) infections are an emerging health pandemic of significant medical importance. The current outbreak has garnered attention by exhibiting unique characteristics of devastating neurodevelopmental defects in newborns of infected pregnant women. Over the past year, doctors in Brazil have documented over 4,000 cases of microcephaly in which infants are born with abnormally small heads. Typical symptoms of ZIKV infection include joint pain, fever, and rash. In addition, there is emerging a potential link to the dramatic increase in the reported cases of Guillain-Barré syndrome, another rare disorder of the peripheral nervous system characterized by muscle weakness and paralysis; in severe cases, Zika patients require life support. Meanwhile, belong to the same family as ZIKV, Dengue virus (DENV) is the most common human arboviral infection, and the most important public health threat from mosquito-borne viral pathogens causing an estimated 100 million cases of dengue fever and half a million cases of dengue hemorrhagic fever (DHF) per year. Of those infected with DHF, 90% are children who ultimately succumb and make up the 5% of people who die of the infection. As Dengue is endemic on all continents except Europe, over half of the world’s population is at risk of infection. Over the past fifty years, incidents of dengue infection have increased by over 30-fold. Currently, there is no vaccine against ZIKV. Clinical trials of DENV vaccines have shown promising results, but prototype vaccines remain inadequate against all four DENV serotypes. One critical challenge to the development of effective vaccines is our incomplete ability to examine and understand the protective humoral immunity against the virus. This challenge is attributed to the limitation of the current technologies to provide a comprehensive profile of the protective neutralizing antibodies in dengue infection. In this application, we propose using single-cell antibody nanowells (SCAN), an innovative single-cell technology, to quickly and efficiently screen individual B-cells for antigen specific products. Using our SCAN technology, we focus on three aspects: 1. Identifying and isolating human natural monoclonal antibodies that recognize ZIKV and DENV 2. Screening for neutralizing capabilities of the monoclonal antibodies 3. Mapping the neutralizing epitopes on the virus in order to design effective vaccine
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017 2:17:26 PM
Research Description
Immunological regulation by T cells; structural interactions between ligand pairs linked to T cell interaction as defined by X-ray crystallography and functional studies.
Department:
Oral Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/22/2015
Research Description
Molecular mechanisms of pathogenesis of gram-negative anaerobic bacterial species; bacterial/host cell interactions
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
7/25/2017 3:50:36 PM
Research Description
Pathogenesis of systemic lupus erythematosus in humans and animal models. Novel disease markers.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
6/12/2017 12:19:16 PM
Research Description
Biology of Kaposi's sarcoma-associated herpesvirus (KSHV); role of latency-associated nuclear antigen (LANA) in transcriptional regulation, viral DNA replication, and episomal segregation in latently-infected cells; role of virus-encoded micro RNAs.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/1/2016
Research Description
Defining the cellular and molecular mechanisms by which T cells contribute to immunity against respiratory pathogens
Department:
Pediatrics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
7/24/2017
Research Description
Prediction, immunopathogenesis, genetics and prevention and care of Type 1 diabetes.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
6/1/2016 3:26:11 PM
Research Description
Molecular Genetics and Biology of Pathogenic Bacteria; Drug Resistance
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
5/23/2016 9:19:26 AM
Research Description
My laboratory works on the fundamental biology of stem cells. Our goal is to design test and bring new cell based therapies to the clinic. How stem cells are involved in cancer and the creation of a supportive "cancer niche" are two primary areas of res
Department:
Periodontology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/26/2017 11:02:57 AM
Research Description
Shaddox main research study, funded by the National Institutes of Health, is aimed at evaluating immunological, microbiological and genetic factors involved with localized aggressive periodontal disease. This is a rare type of gum disease affecting mostly young children and adolescents
Department:
Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/22/2015
Research Description
Mechanisms of autoantibody production.
Department:
Biomedical Engineering
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
7/5/2017
Research Description
My research centers on the engineering of cell-based tissues for the treatment of Type 1 diabetes, specifically the development of novel biomaterials for: nano-scale encapsulation of cells; three-dimensional scaffolds; in situ oxygen and drug release; and bioactive nanoparticles. Through the fabrication of novel biomaterials capable of actively interfacing with the host, I seek to modulate the graft environment to favor the survival and function of the implanted cells. My research spans from material development to extensive preclinical model evaluation to clinical translation.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/12/2017 9:14:06 AM
Research Description
Pathogenesis of oncogenic viruses, virus-host interactions, host immunity to viruses, viral latency, viral noncoding RNAs.
Department:
Oral Biology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017
Research Description
Pathogenesis of oncogenic herpesviruses, mechanisms of viral immune evasion, epigenetic regulation of gammaherpesvirus infection, viral genetics
Department:
Ophthalmology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2017 12:00:46 PM
Research Description
Dr. Tuli is board-certified in ophthalmology. Her interests include cataracts, corneal transplants, ocular surface cancers, dry eye disease and infectious eye diseases.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
No
Last Updated
9/7/2017
Research Description
Dr. Amy Vittor studies factors that drive the emergence of vector-borne diseases. She conducted her doctorate on malaria and deforestation in the Peruvian Amazon, showing that a strong positive association exists between the abundance of malaria vectors and anthropogenic land use change. During her medical training, she treated patients with HIV and tuberculosis in Botswana, Kenya and Panama, and conducted malaria bed net implementation research in a United Nations Millennium Village in Ethiopia with the Earth Institute at Columbia University. Driven by a desire to better understand why arboviruses emerge where and when they do, she turned her attention to arboviral transmission. She studied dengue epidemiology in Kenya with the Centers for Disease Control and Prevention in Nairobi as a Fogarty International Clinical Fellow, and subsequently moved to Panama to examine the epidemiology of Venezuelan equine encephalitis and the emergent Madariaga encephalitis. At present, her research continues to look at the effect of land use change on vector-borne disease, but now also includes an examination of the role of host susceptibility and the population’s prior immune history. She also attends on the infectious diseases service at the University of Florida Shands hospital.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/26/2017 11:42:06 AM
Research Description
Molecular and epigenetic mechanisms infection and other inflammatory conditions underlying inflammatory polarization of antigen presenting cells (APC) including macrophages and dentritic cells in infectious disease (HIV-1) and autoimmune disease (type 1 diabetes).
Department:
Oral Biology
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2017 3:22:14 PM
Research Description
The major focus of my research program is dedicated to the understanding of homeostatic mechanisms which are disrupted in autoimmunity, inflammatory diseases and cancer processes. I have investigated regulatory mechanisms ranging from those associated with the adaptive immune response [regulatory T cells and dendritic cells] and innate immune responses [monocytes, macrophages and neutrophils] to those associated with mucosal homeostasis [epithelial cell immune responses]. In short, I spent my formal training deciphering the lack of regulatory responses in type 1 diabetes (T1D) using the non-obese diabetic (NOD) mouse model; developing therapies to improve this phenomenon; and finally evaluating mechanisms of therapeutic efficacy (or lack thereof). In recent years, I have focused my research on the role of epithelial and stromal cells in innate immune responses and how these non-traditional innate mediators contribute to immune tolerance, systemic immunity, and cancer progression.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017
Research Description
Our current research falls within the general themes of host-pathogen interactions, and is divided into two major areas 1) Molecular studies of HIV and HCV pathogenesis and drug resistance and 2) Ecology of indigenous microbial communities associated with human infections.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/22/2015
Research Description
Molecular Immunology, Innate immune responses to autoimmunity
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2017 9:18:22 AM
Research Description
Diabetes research.
Department:
Pediatrics
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2017
Research Description
The Wynn laboratory is focused on the investigation of neonatal-specific innate immune cellular function and inflammatory signaling during sepsis as well as development of novel therapeutic immunomodulatory strategies aimed at improving sepsis outcomes. Sepsis represents a significant clinical problem in the developmentally immature preterm neonate where attack rates may reach 60 percent with a 40 percent rate of death/major disability in developed countries. We employ both preclinical mechanistic investigations in association with observational human studies to improve our understanding of the neonatal-specific host response to sepsis. We use a wide variety of molecular and genetic techniques to interrogate the immune response viain vivo, ex vivo, and in vitro approaches. Applications of our work include improving the accuracy of sepsis diagnostic methods, identification of prognostic and clinical stratification markers, and discovery of potential opportunities for translational interventions aimed at improving infection-related outcomes.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
6/13/2017
Research Description
Mechanisms of irisin on converting white adipose tissue into brown adipose tissue for fighting obesity and type 2 diabetes; Roles of mesenchymal stem cells in regulating hematopoietic "niches" in normal and lupus patients; Transdifferentiation of human
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Accepting Students if
Funding Obtained
No
Last Updated
5/23/2016 2:15:42 PM
Research Description
1. Molecular defects in immunoglobulin transcriptome repertoires in health and disease. 2. HIV-1 population structure, evolution, persistence and activation during disease progression. 3. HPV prevalence, population structure, persistence and fluctuation
Department:
Infectious Diseases and Pathology
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
6/13/2017
Research Description
The goal of my laboratory is to determine the transcriptional regulation of intestinal immune responses, host-microbe interactions, and lymphocyte development in health and in disease.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Accepting Students if
Funding Obtained
Yes
Last Updated
7/12/2017
Research Description
Crohn’s Disease, Inflammatory Bowel Disease (IBD), Ulcerative Colitis 1) Molecular mechanism of fibrosis in Crohn's disease. The goal of this project is to determine the molecular mechanism whereby inflammation contributes to fibrosis in Crohn's disease using animal and cell culture models of the disease. 2) Therapy directed at preventing or treating fibrosis in IBD. The goal of this project is to identify pathways or novel therapies to prevent or treat fibrosis in Crohn’s disease. 3) Noninvasive method to detect fibrosis in Crohn's disease patients. The goal of this translational project is to develop methods to noninvasively detect fibrosis. This method will be used to monitor the natural history of Crohn's disease and determine the ability of new medications to alter the natural history of the disease. 4) Intestinal drug targeting. The goal of this work is to more effectively deliver drugs to regions of bowel using the oral route. This is aimed at decreasing systemic side effects of immunosuppressive medications. 5) Delivery of clinical care to IBD patients. Several prospective and retrospective projects examine pathogenesis, disease assessment, disease complications, and therapy outcomes in Crohn's disease and ulcerative colitis. A special area of interest is in care of college students with Crohn’s disease and ulcerative colitis.

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