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Department:
Oral Biology
Concentrations:
Accepting Students
Yes
Last Updated
6/1/2016
Research Description
Research Description: Developmental biology; Developmental mechanisms of evolutionary change; Cell type evolution; Genetic, genomic, and environmental causes of birth defects; Disorders of sex development.
Department:
Oral Biology
Concentrations:
Accepting Students
No
Last Updated
5/31/2016
Research Description
My research area is to elucidate the regulatory pathways of oral bacteria, with particular focus on biofilm formation and stress tolerance that can modulate the virulence of oral bacteria and enhance the pathogenic potential of oral biofilms. Stemming from the original AtlA work, another major research area is to investigate the molecular basis for regulation of autolysis of S. mutans by gene products that have major effects on traits related to virulence. This research focuses on the characterization of a pair of dicistronic operons, lrg and cid-like, that significantly affected autolysis and biofilm formation by S. mutans.
Department:
Infectious Diseases and Pathology
Concentrations:
Accepting Students
No
Last Updated
5/23/2016 9:24:58 AM
Research Description
Cellular and molecular bases of host-parasite interactions; immunology of hemoparasitic diseases.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
Yes
Last Updated
5/24/2016 1:10:58 PM
Research Description
Natural history of Type 1 Diabetes; cellular immunology, clinical trials for disease prevention and reversal; beta cell regeneration; pancreatic pathology; microbiome; translational medicine.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Last Updated
5/24/2016 7:44:54 AM
Research Description
Her research interest is in immune regulation, autoimmunity, as well as lung inflammation. Her work has an important impact in the control of autoimmune diseases such as multiple sclerosis and inflammatory bowel disease, as well as in airway inflammation.
Department:
Infectious Diseases and Pathology
Concentrations:
Accepting Students
No
Last Updated
5/24/2016 1:48:15 PM
Research Description
Molecular biology of parasitic and ehrlichial diseases of cattle; development of recombinant vaccines and diagnostic tests, molecular mechanism of pathogenesis.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Last Updated
6/1/2016 11:01:32 AM
Research Description
The focus of the lab is on the molecular basis of pathogenesis of the herpesviruses and the application of these concepts and control of latent gene expression. Specifically we have recently been investigating the role of HSV non-coding RNAs on the regula
Department:
Oral Biology
Concentrations:
Accepting Students
No
Last Updated
6/11/2015 4:52:32 PM
Research Description
Streptococcal protein translocation; stress responses; membrane biogenesis; biofilm formation; bacterial adhesion; functional amyloid formation; host/pathogen interactions; immunomodulation by monoclonal antibodies; structure/function of streptococcal sur
Department:
Medicine
Concentrations:
Accepting Students
No
Last Updated
6/10/2016
Research Description
The goal of our work is to understand how misfolded alpha-1-antitrypsin causes cellular injury in liver and innate immune cells and to develop rational therapies to modulate this injury. To accomplish this goal we use cellular and animal models and transl
Department:
Institute for Therapeutic Innovation
Concentrations:
Accepting Students
Yes
Last Updated
5/31/2016 12:17:44 PM
Research Description
My research focuses on designing optimized therapeutic regimens for antiviral compounds active against viruses that pose a significant threat to global public health including influenza virus, dengue virus, chikungunya virus, hepatitis C virus, and HIV.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Last Updated
5/23/2016 12:16:39 PM
Research Description
Regulation of immunity & autoimmunity; prediction, intervention, and treatment for type 1 diabetes. The lab is focused on the mechanisms by which regulatory T cells maintain peripheral immune tolerance in the context of type 1 diabetes.
Department:
Oral Biology
Concentrations:
Accepting Students
Yes
Last Updated
5/23/2016 11:50:09 AM
Research Description
Environmental regulation of bacterial gene expression and virulence.
Department:
Pediatrics
Concentrations:
Accepting Students
No
Last Updated
5/25/2016
Research Description
Cardiovascular gene therapy; adeno-associated viral vectors.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Last Updated
5/31/2016
Research Description
Characterize the immune suppressor mehanisms involved in the develeopment of HCC in the background of cirrhosis to identify novel targets that can lead to development of new immune activating strategies and/or prognostic and predictive immune biomarkers.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Last Updated
5/24/2016 12:07:02 PM
Research Description
My laboratory is examining mechanisms for loss of human beta cells in type 1 diabetes and ways to restore functional beta cell mass. Studies will be conducted using human samples obtained through the Network for Pancreatic Organ Donors with Diabetes (nPOD) and isolated human islets or cell lines.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Last Updated
10/12/2016
Research Description
Department:
Oral & Maxillofacial Surgery and Oral Diagn Sci
Concentrations:
Accepting Students
No
Last Updated
5/24/2016 9:40:44 AM
Research Description
Underlying pathogenesis of autoimmune Sjogren's syndrome Development of diagnostic and therapeutic strategies for Sjogren's syndrome Radiation-induced dry mouth in head and neck cancer patients Stem cell research to restore secretory dysfunction
Department:
Oral Biology
Concentrations:
Accepting Students
No
Last Updated
5/23/2016 1:09:57 PM
Research Description
The current research projects are 1) studies of microRNAs in the regulation of toll-like receptor signaling pathways in innate immune response and their relationship to autoimmune diseases, including rheumatoid arthritis and systemic lupus erythematosus and periodontal disease; 2) microRNAs in oral cancer as biomarkers and targets for therapy; 3) biological function of subcellular rod/ring structures
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Last Updated
5/23/2016 12:04:53 PM
Research Description
Development of novel gene transfer tools, small animal models for the study of HIV and cancer, vaccines and immuno-therapeutic strategies for these diseases.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Last Updated
6/13/2016 7:47:33 AM
Research Description
Translational research Cell-based therapy for type 1 diabetes Dr. Clare-Salzler is a JDRF, NIH-funded basic and clinical scientist investigating the autoimmune process that causes Type 1 Diabetes (T1D). The major focus of the laboratory is on the role o
Department:
Infectious Diseases and Pathology
Concentrations:
Accepting Students
Yes
Last Updated
5/31/2016
Research Description
Mycobacterium tuberculosis, the causative agent of tuberculosis. Investigate how these bacteria survive and grow within human cells to cause TB. We are using this knowledge to develop a safe, effective vaccine to protect people against infection.
Department:
Pediatrics
Concentrations:
Accepting Students
Yes
Last Updated
10/6/2015
Research Description
My current research as an Assistant Scientist in the Department of Pediatrics focuses on understanding the contribution of neurological impairment in neuromuscular disorders by combining her expertise in clinical assessment with novel therapies that rely on correcting the fundamental genetic defect, which underlies most inherited neuromuscular conditions. Genetic therapies offer the most specific form of treatment to improve and restore both the muscular and the neurological impairments in neuromuscular disease. My work serves as the foundation for a revolution in the care of this patient population who previously had few, if any, effective therapies for this type of life threatening and debilitating conditions.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
Innate and acquired immune mechanisms in the pathogenesis of kidney disease: chronic allograft mephropathy, diabetes and lupus nephritis.
Department:
Infectious Diseases and Pathology
Concentrations:
Accepting Students
Yes
Last Updated
5/23/2016
Research Description
Department:
Infectious Diseases and Pathology
Concentrations:
Accepting Students
No
Last Updated
5/31/2016 11:44:55 AM
Research Description
Interests of the Dame lab include emerging and re-emerging pathogens of animals and man; molecular biology of the malaria parasite; drug and vaccine target identification in Plasmodium falciparum. Current projects include: Analysis of the population genetic structure of P falciparum in Haiti Improved diagnosis of asymptomatic, submicroscopic malaria infections
Department:
Oral Biology
Concentrations:
Accepting Students
Yes
Last Updated
6/1/2016 9:20:45 AM
Research Description
The primary goal of the human microbiome project is to increase our understanding of the structure and function of our microbiota and to elucidate their role in health and predisposition to disease. One of the best-understood human-associated microbial systems is the oral microbiome. The Davey lab uses a combination of molecular genetics, bacterial physiology, and biochemical techniques to study the oral microbiome. In particular, we are focused on the regulator mechanisms (environmental and interspecies signals) that control the pathogenic state of the oral anaerobe, Porphyromonas gingivalis.
Department:
Oral Biology
Concentrations:
Accepting Students
No
Last Updated
5/24/2016 9:47:41 AM
Research Description
The research in my laboratory focuses on the role of host defense peptides in the defense against infectious diseases at mucosal surfaces. Defensins and cathelicidins are two classes of peptides that play important roles in innate immune defenses against microbial pathogens. They exhibit broad-spectrum antimicrobial activity, and also modulate the innate immune system. We are studying them in two different ways: First, we are examining how their genes are regulated in the lung and in the oral cavity, by factors such as vitamin D and cytokines, to develop new ways of treating and preventing infectious diseases. This utilizes both molecular biology approaches with cultured cells as well as in vivo infection models. Second, we are working with a company to develop novel molecules based on these naturally occurring peptides, to treat and prevent oral and systemic microbial infections. This involves quantifying the in vitro activity of these compounds against microbial pathogens, as well as testing then in mouse models of infection.
Department:
Medicine
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
Infectious Diseases, mathematical modeling, chemotherapy, pharmacokinetics, pharmacodynamics, bacteria, virus, and fungi
Department:
Pediatrics
Concentrations:
Accepting Students
No
Last Updated
6/29/2016 1:08:37 PM
Research Description
Effect of immunosuppression on anti-GAA antibody development in patients with Pompe disease, clinical trial studies as part of CARRA (Childhood Arthritis and Rheumatology Research Alliance)

Kevin P. Fennelly, MD

Department:
Medicine
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
Assessing infectiousness of tuberculosis and other infections via cough aerosols. ; TB diagnostics
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Last Updated
5/23/2016
Research Description
Molecular biology and genetics of RNA virus replication.
Department:
Oral Biology
Concentrations:
Accepting Students
Yes
Last Updated
9/26/2016
Research Description
Molecular mechanisms of periodontal diseases.
Department:
Oral Biology
Concentrations:
Accepting Students
Yes
Last Updated
9/26/2016
Research Description
Research in my lab is focused in areas of host-pathogen interaction geared toward developing a better understanding of the host mechanisms and bacterial structures important in infection-elicited inflammation. To accomplish this we use a variety of approaches including molecular, cellular, immunological, and animal modeling to develop a synthetic understanding of relevant systems. Work has centered on identification of host cell receptors engaged by key bacterial structures/adhesins, and the subsequent signaling pathways activated which lead to immune activation, with the goal to harness those factors in a manner that can lead to re-establishment of normal tissue homeostasis. Current investigative lines utilize the bacterium Porphyromonas gingivalis as a model oral organism to study key facets of anaerobic bacterial infection and contribution of bacterial structures such as capsular polysaccharides in the development of inflammation and oral bone loss. A particular area of interest is identification of molecular targets and pathways that could serve as novel points for therapeutic intervention to augment available treatments aimed to limit periodontal tissue destruction. In addition to the work focusing on the pathogenesis of oral disease, our group engaged in collaborative studies that have been seminal in identifying associations of oral bacterial infection with cardiovascular disease. Work in this area provides experimental evidence that P. gingivalis is a potential risk factor for atherosclerosis, and that this infection-elicited acceleration can be prevented through immunization. The underlying mechanisms of this association are not well defined. More recently we have become interested in nuclear hormone receptors including liver x receptors and peroxisome proliferator-activated receptors in the development of bacteria-elicited inflammation, and contribution of inflammatory cues at sites of infection in the pathogenesis of periodontal disease. Furthermore, collaborative studies have begun to explore P. gingivalis interactions with adipocytes, as well as integrative studies to investigate aspects of P. gingivalis / HIV co-infection.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Last Updated
1/19/2017 1:06:57 PM
Research Description
My clinical practice is focused on inflammatory bowel disease, Crohn’s and ulcerative colitis, and on allergic gastrointestinal disorders, eosinophilic GI disorders and GI mast cell disorders. I have approximately 2000 patient visits per year which is important for both my clinical and bench research. My bench research focuses on innate immune mechanisms of gut inflammation. Specifically, we study innate lymphoid cell (ILC) plasticity in inflammation and infection, ILC and T cell interactions in inflammation, and mast cell behavior in the GI tract.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Last Updated
5/23/2016 12:53:49 PM
Research Description
We use molecular genetics and genomics coupled with animal models to examine how a normal intestinal bacterium, Oxalobacter formigenes, helps prevent kidney stones. We also use genetics and animal models to examine pathogenesis of disease caused by Vibrio vulnificus.
Department:
Pediatrics
Concentrations:
Accepting Students
No
Last Updated
6/3/2016
Research Description
Prevention and Reversal of Type 1 diabetes
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Last Updated
6/13/2016
Research Description
My area of interest is social determinants of health, impact of stress in childhood on health outcomes, perinatal outcomes.
Department:
Pediatrics
Concentrations:
Accepting Students
No
Last Updated
6/10/2016 11:45:40 AM
Research Description
Gene therapy for the inherited bleeding disorder hemophilia; immunology of in vivo gene transfer; tolerance induction to therapeutic proteins.
Department:
Psychiatry
Concentrations:
Accepting Students
No
Last Updated
6/29/2016
Research Description
1. Gene therapy using recombinant adeno-associated virus-based vectors for the treatment of brain and thyroid disorders 2. Parvovirus-host interactions
Department:
Medicine
Concentrations:
Accepting Students
No
Last Updated
6/10/2016
Research Description
Innate defense mechanisms against resistant Gram-negative bacteria Influenza and emerging infectious diseases
Department:
Medicine
Concentrations:
Accepting Students
Yes
Last Updated
10/4/2016
Research Description
Vaccines are one of the greatest achievements of biomedical science. Most vaccines are injected. There is a growing interest in developing and improving vaccines that can be inhaled. This delivers the vaccine directly to the mucosal surfaces that line the nose and lungs, which is a more effective way to produce immunity against respiratory pathogens such as pneumococcus and influenza. As these mucosal vaccines are also relatively cheap and easy to apply, they would also be suitable for use in developing countries and during emergencies. Developing safe and effective mucosal vaccine adjuvants, which help to boost targeted immune response, is key to the development of mucosal vaccines. Currently, there is no approved mucosal vaccine adjuvant in U.S. Cyclic dinucleotides (CDNs) are promising mucosal vaccine adjuvant candidates. They elicit potent and balanced humoral and cellular immune response protecting animals from virus and bacterial infection. CDNs include cyclic di-AMP (CDA), cyclic di-GMP (CDG) and the newly discovered 2’5’-3’5’-cyclic GMP-AMP (2’3’-cGAMP). STING (stimulator of interferon genes) is the mammalian receptor for CDNs. We first showed that the mucosal adjuvant CDNs enhance antigen uptake and process in animals and directly activates dendritic cells (DC) in vivo. We further showed that STING-dependent TNFa production is critical for the mucosal adjuvant activity of CDNs in vivo. Our goal is to i) decipher the in vivo cellular and molecular mechanism of action of CDN; ii) advance CDN as safe and efficacious mucosal vaccine adjuvants in human. The approaches we are using including knockout, knockin mice, conditional knockout, and conditional WT mice. We are also endeavoring to expand our research in human samples and cells. Other research interests in the lab include i) Understanding the effects of common human STING variations on licensed pneumococcal vaccines Pneumovax®23 and Prevnar13® effectiveness in vivo; ii) Understanding the role of STING in host defense against pneumococcal infections in vivo.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Last Updated
5/24/2016 1:37:13 PM
Research Description
Molecular mechanisms of host-pathogen interactions; virulence mechanism of Pseudomonas aeruginosa infection and development of antimicrobial strategies; Cellular reprogramming and genome editing
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Last Updated
7/24/2015
Research Description
Microbial pathogenesis, antibiotic resistance, microbial genetics, molecular epidemiology, microbial ecology.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Last Updated
6/11/2015 4:54:16 PM
Research Description
Pathogenesis of noroviruses, innate immune responses to norovirus infection, and molecular mechanisms of norovirus replication. Mucosal immunity to, and pathogenesis, of murine norovirus infection.
Department:
Biomedical Engineering
Concentrations:
Accepting Students
Yes
Last Updated
6/1/2016
Research Description
The Biomaterial Immuno-Engineering Lab focuses on the engineering of biomaterial-cell interactions, and targeted controlled release of immune modulating factors in order to direct immune cell function.
Department:
Microbiology & Cell Science
Concentrations:
Accepting Students
Yes
Last Updated
6/10/2016 12:21:09 PM
Research Description
Our overall goal is to elucidate the mechanisms by which Leishmania parasites persist in infected hosts. Specifically, we investigate how the parasite's niche within macrophages is formed. In addition, we seek to identify the virulence factors that Leishmania elaborate
Department:
Urology
Concentrations:
Accepting Students
No
Last Updated
5/31/2016 10:44:30 AM
Research Description
Our research is focused on tumor immunology, including immunotherapy and mechanisms of immune escape in urologic cancers (prostate, kidney, bladder) in both clinical and experimental settings.
Department:
Periodontology
Concentrations:
Accepting Students
No
Last Updated
5/31/2016 9:47:01 AM
Research Description
Major interests are to examine the role of major periodontal pathogens causal association with systemic diseases including atherosclerosis, rheumatoid arthritis, Alzheimer’s disease, diabetes, stroke, and oral cancer.
Department:
Oral Biology
Concentrations:
Accepting Students
Yes
Last Updated
5/24/2016
Research Description
My Laboratory investigates the molecular factors that promote virulence in the opportunistic Gram-positive pathogens Streptococcus mutans and Enterococcus faecalis. S. mutans is a major pathogen in dental caries and a leading causative agent of infective endocarditis. In S. mutans, our current efforts focus on the characterization of the Spx global regulator, and its role in controlling stress responses and biofilm formation. The second S. mutans project, in collaboration with Dr. Jacqueline Abranches, focuses on the characterization of a collagen binding protein responsible for intracellular invasion of human heart and oral tissues, a trait that is potentially linked to increased virulence, recurrent infection and chronic inflammation. The characterization of stress responses is also the theme of our research with E. faecalis, a leading cause of hospital-acquired infections. In this project, we are investigating the interplay between the stringent response, a major bacterial stress response mechanism for adaptation to changing environments, with other prominent stress regulators and how these interactions influence the ability of E. feacalis to survive under adverse conditions.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Last Updated
5/23/2016 12:06:25 PM
Research Description
Dr. Lewin's current research involves the development of gene and pharmacological therapies for neurodegenerative diseases of the retina and the central nervous system. The group has developed a mouse model of Age Related Macular Degeneration, a common blinding disease of the elderly.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Last Updated
6/30/2016 3:24:12 PM
Research Description
My group uses sophisticated in vitro and murine infection models to develop regimens for investigational and marketed antibiotics that maximize the killing of bacterial “superbugs” and prevent other bacteria from becoming “superbugs.” The interaction of the host’s immune system with antibiotics to achieve these goals is also assessed. Microbes include multidrug-resistant Pseudomonas, Acinetobacter, Klebsiella, and E. coli. I also work with drug-susceptible Mycobacterium tuberculosis.
Department:
Pediatrics
Concentrations:
Accepting Students
Yes
Last Updated
5/23/2016
Research Description
The research in my lab is focus on developing new therapies of lysosomal storage diseases (LSDs) based on the understanding of molecular mechanisms of the pathogenesis of these diseases. These inherited metabolic conditions are caused by defects in a wide spectrum of lysosomal and a few non-lysosomal proteins resulting in accumulation of undigested substrates, resulting in dysfunction of lysosomal/endosomal system. The almost 60 different LSDs are individually rare genetic conditions, but, collectively, the incidence is approximately 1/2,000-3,000 live births. Since lysosomal/endosomal system is essential for cell homeostasis, this “inborn organelle disorders” results in multi-systemic diseases, and predominantly affecting the brain. The study LSDs allowed the discovery of several biological processes including the discovery of mannose-6-phosphate targeting system and currently gives insights into neurodegenerative mechanism in Alzheimer and Parkinson’s diseases. In LSDs, the development of clinical symptoms usually correlates with a level of residual deficient enzyme activity. In patients with late onset forms of LSDs, a residual lysosomal activity is a result of missense mutations, which partially preserves catalytic enzyme function but mostly impairs the early folding process in the ER. These mutant lysosomal enzymes do not reach its appropriate conformation, and subsequently are directed to ER-associate degradation (ERAD) pathway, and are ultimately degraded by the ubiquitin-proteosome system. In this context, small molecule therapeutics are an attractive approach to treat LSDs. Enzyme-enhancement agents, including pharmacological chaperones (PC), are small molecules which are able to assist a mutant misfolded protein to achieve a native-like conformation in the endoplasmic reticulum (ER), allowing it to escape the ERAD pathway, and reach the lysosome. An advantage of this approach is that small molecules are much more likely to cross the blood brain barrier and reach neuronal cells, which are dramatically affected in LSDs. In addition, principles learned in treating one type of LSD can be applied not only to other LSDs, but also to other misconformation protein diseases, which is also feature of common neurodegenerative conditions.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Last Updated
6/27/2016 10:15:56 AM
Research Description
Genetics of resistance to autoimmune diabetes; oxidative burden of the beta cell.
Department:
Environmental Health
Concentrations:
Accepting Students
Yes
Last Updated
5/25/2016 12:22:13 PM
Research Description
Pathogenic mechanisms of Shigella and Chlamydia Evolution and emergence of Shiga toxin-producing Shigella flexneri Cell wall metabolism and cell division processes of Chlamydia spp. Surveillance of non-HIV sexually transmitted infections in Haiti Laboratory capacity building
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Last Updated
6/3/2016 1:48:54 PM
Research Description
Genetics of susceptibility to autoimmune disease, vitiligo, education research.
Department:
Periodontology
Concentrations:
Accepting Students
No
Last Updated
6/3/2016
Research Description
We focus primarily on osteoimmunology, which is the study of interactions between immune cells, immune mediators, and immune signaling in skeletal biology. In particular, we study the differentiation of bone-resorbing osteoclast cells in response to bone
Department:
Infectious Diseases and Pathology
Concentrations:
Accepting Students
No
Last Updated
5/24/2016 11:07:30 AM
Research Description
Retrovirus vector for gene transfer based on foamy virus. Comparative and experimental pathology.
Department:
Neurosurgery
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
Department:
Infectious Diseases and Pathology
Concentrations:
Accepting Students
No
Last Updated
5/23/2016 2:14:05 PM
Research Description
Intestinal disorders (IBD, colon cancer) and oral vaccine delivery
Department:
Surgery
Concentrations:
Accepting Students
Yes
Last Updated
5/24/2016 12:53:08 PM
Research Description
The laboratory focuses on the innate and adaptive immune response to severe critical illness, including trauma, and surgical sepsis. Working with cell culture, animal models and clinical observation and interventional trials, the laboratory focuses on studying myelopoiesis, myeloid cell development, MDSCs and mature dendritic cell responses to severe trauma, severe sepsis, chronic critical illness and the PICS syndrome.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
Yes
Last Updated
5/24/2016 1:55:29 PM
Research Description
Genetic analysis of systemic lupus erythematosus (SLE) susceptibility using mouse models, immune metabolism and use of metabolic inhibitors to treat lupus Microbiome and lupus
Department:
Medicine
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
Molecular epidemiology and transmission modeling of Vibrio cholerae in Haiti and Bangladesh.
Department:
Oral Biology
Concentrations:
Accepting Students
No
Last Updated
5/24/2016
Research Description
My main research projects focus on investigating the relationship between oral alkali production from arginine and caries experience in children and adults. These studies offer a unique fusion of cutting-edge microbiome analysis coupled with microbiological, physiologic and genetic characterization of the constituents of the oral microbiome in the context of their abilities to modulate the pH, and thus the cariogenic potential of oral biofilms. The studies are founded on the most contemporary and scientifically-supported view of caries development and have a high likelihood of leading to a major breakthrough in understanding the caries process, and ultimately to novel clinical practice paradigms that incorporate oral alkali production into caries diagnosis, prevention and treatment.
Department:
Oral Biology
Concentrations:
Accepting Students
Yes
Last Updated
6/8/2016
Research Description
Primary areas of interest in the Nguyen lab focus on deciphering the autoimmune process of Sjögren’s syndrome using human patients and animal models. Sjögren’s syndrome is a systemic, rheumatic, autoimmune disease primarily targeting the salivary/lacrimal glands resulting in xerostomia/keratoconjunctivitis sicca. It is one of the most prevalent automimmune disorders in the US, affecting approximately four million individuals, predominantly middle-age women (nine out of 10 patients). The precise etiology of the disease is difficult to pinpoint in the human population. Our lab concentrates on the development of animal models to 1) examine the temporal change in the pathophysiological process, utilizing microarray technology, and 2) determine the genetic susceptibility loci, using recombinant animal models. To address the immunological process of the disease, the Nguyen lab investigates the biological function of TH17 cells, their signal transduction in immune system regulation, and their function. This area of research is aimed at identifying potential therapeutic targets for gene therapy. Lastly, the Nguyen lab is adopting the use of a single cell analysis approach, called microengraving technology, to resolve the heterogeneity of the infiltrating cells in the salivary/lacrimal glands and identify novel biomarkers for disease diagnosis.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
Yes
Last Updated
6/10/2016 2:17:26 PM
Research Description
Immunological regulation by T cells; structural interactions between ligand pairs linked to T cell interaction as defined by X-ray crystallography and functional studies.
Department:
Oral Biology
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
Molecular mechanisms of pathogenesis of gram-negative anaerobic bacterial species; bacterial/host cell interactions
Department:
Medicine
Concentrations:
Accepting Students
No
Last Updated
5/23/2016 3:50:36 PM
Research Description
Pathogenesis of systemic lupus erythematosus in humans and animal models. Novel disease markers.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Last Updated
5/23/2016 12:19:16 PM
Research Description
Biology of Kaposi's sarcoma-associated herpesvirus (KSHV); role of latency-associated nuclear antigen (LANA) in transcriptional regulation, viral DNA replication, and episomal segregation in latently-infected cells; role of virus-encoded micro RNAs.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Last Updated
6/1/2016
Research Description
Defining the cellular and molecular mechanisms by which T cells contribute to immunity against respiratory pathogens
Department:
Pediatrics
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
Prediction, immunopathogenesis, genetics and prevention and care of Type 1 diabetes.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Last Updated
6/1/2016 3:26:11 PM
Research Description
Molecular Genetics and Biology of Pathogenic Bacteria; Drug Resistance
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Last Updated
5/23/2016 9:19:26 AM
Research Description
My laboratory works on the fundamental biology of stem cells. Our goal is to design test and bring new cell based therapies to the clinic. How stem cells are involved in cancer and the creation of a supportive "cancer niche" are two primary areas of res
Department:
Periodontology
Concentrations:
Accepting Students
No
Last Updated
6/13/2016 11:02:57 AM
Research Description
Shaddox main research study, funded by the National Institutes of Health, is aimed at evaluating immunological, microbiological and genetic factors involved with localized aggressive periodontal disease. This is a rare type of gum disease affecting mostly young children and adolescents
Department:
Medicine
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
Mechanisms of autoantibody production.
Department:
Biomedical Engineering
Concentrations:
Accepting Students
No
Last Updated
5/31/2016
Research Description
My research centers on the engineering of cell-based tissues for the treatment of Type 1 diabetes, specifically the development of novel biomaterials for: nano-scale encapsulation of cells; three-dimensional scaffolds; in situ oxygen and drug release; and bioactive nanoparticles. Through the fabrication of novel biomaterials capable of actively interfacing with the host, I seek to modulate the graft environment to favor the survival and function of the implanted cells. My research spans from material development to extensive preclinical model evaluation to clinical translation.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Last Updated
6/13/2016 9:14:06 AM
Research Description
Pathogenesis of oncogenic viruses, virus-host interactions, host immunity to viruses, viral latency, viral noncoding RNAs.
Department:
Oral Biology
Concentrations:
Accepting Students
Yes
Last Updated
8/18/2016
Research Description
Pathogenesis of oncogenic herpesviruses, mechanisms of viral immune evasion, epigenetic regulation of gammaherpesvirus infection, viral genetics
Department:
Ophthalmology
Concentrations:
Accepting Students
No
Last Updated
6/1/2016 12:00:46 PM
Research Description
Dr. Tuli is board-certified in ophthalmology. Her interests include cataracts, corneal transplants, ocular surface cancers, dry eye disease and infectious eye diseases.
Department:
Oral Biology
Concentrations:
Accepting Students
No
Last Updated
5/23/2016
Research Description
Mechanisms of antibiotic resistance and antibiotic resistance in biofilms.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Last Updated
6/29/2016 11:42:06 AM
Research Description
Molecular and epigenetic mechanisms infection and other inflammatory conditions underlying inflammatory polarization of antigen presenting cells (APC) including macrophages and dentritic cells in infectious disease (HIV-1) and autoimmune disease (type 1 diabetes).
Department:
Oral Biology
Concentrations:
Accepting Students
No
Last Updated
6/1/2016 3:22:14 PM
Research Description
The major focus of my research program is dedicated to the understanding of homeostatic mechanisms which are disrupted in autoimmunity, inflammatory diseases and cancer processes. I have investigated regulatory mechanisms ranging from those associated with the adaptive immune response [regulatory T cells and dendritic cells] and innate immune responses [monocytes, macrophages and neutrophils] to those associated with mucosal homeostasis [epithelial cell immune responses]. In short, I spent my formal training deciphering the lack of regulatory responses in type 1 diabetes (T1D) using the non-obese diabetic (NOD) mouse model; developing therapies to improve this phenomenon; and finally evaluating mechanisms of therapeutic efficacy (or lack thereof). In recent years, I have focused my research on the role of epithelial and stromal cells in innate immune responses and how these non-traditional innate mediators contribute to immune tolerance, systemic immunity, and cancer progression.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Last Updated
6/3/2016
Research Description
Our current research falls within the general themes of host-pathogen interactions, and is divided into two major areas 1) Molecular studies of HIV and HCV pathogenesis and drug resistance and 2) Ecology of indigenous microbial communities associated with human infections
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
Molecular Immunology, Innate immune responses to autoimmunity
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Last Updated
5/24/2016 9:18:22 AM
Research Description
Diabetes research.
Department:
Pediatrics
Concentrations:
Accepting Students
No
Last Updated
5/24/2016
Research Description
The Wynn laboratory is focused on the investigation of neonatal-specific innate immune cellular function and inflammatory signaling during sepsis as well as development of novel therapeutic immunomodulatory strategies aimed at improving sepsis outcomes. Sepsis represents a significant clinical problem in the developmentally immature preterm neonate where attack rates may reach 60 percent with a 40 percent rate of death/major disability in developed countries. We employ both preclinical mechanistic investigations in association with observational human studies to improve our understanding of the neonatal-specific host response to sepsis. We use a wide variety of molecular and genetic techniques to interrogate the immune response viain vivo, ex vivo, and in vitro approaches. Applications of our work include improving the accuracy of sepsis diagnostic methods, identification of prognostic and clinical stratification markers, and discovery of potential opportunities for translational interventions aimed at improving infection-related outcomes.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Last Updated
5/23/2016
Research Description
Mechanisms of irisin on converting white adipose tissue into brown adipose tissue for fighting obesity and type 2 diabetes; Roles of mesenchymal stem cells in regulating hematopoietic "niches" in normal and lupus patients; Transdifferentiation of human
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Last Updated
5/23/2016 2:15:42 PM
Research Description
1. Molecular defects in immunoglobulin transcriptome repertoires in health and disease. 2. HIV-1 population structure, evolution, persistence and activation during disease progression. 3. HPV prevalence, population structure, persistence and fluctuation
Department:
Infectious Diseases and Pathology
Concentrations:
Accepting Students
Yes
Last Updated
5/24/2016
Research Description
The goal of my laboratory is to determine the transcriptional regulation of intestinal immune responses, host-microbe interactions, and lymphocyte development in health and in disease.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Last Updated
6/6/2016
Research Description
Crohn’s Disease, Inflammatory Bowel Disease (IBD), Ulcerative Colitis

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