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Department:
Infectious Diseases and Pathology
Concentrations:
Accepting Students
No
Last Updated
5/23/2016 9:24:58 AM
Research Description
Cellular and molecular bases of host-parasite interactions; immunology of hemoparasitic diseases.
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
No
Last Updated
5/24/2016 11:04:28 AM
Research Description
Our laboratory is interested in the molecular and cellular basis of aging. There are a number of mechanisms that contribute to the aging process at the molecular and cellular level. These mechanisms include, but are not limited to: (1) molecular damage
Department:
Ophthalmology
Concentrations:
Accepting Students
No
Last Updated
6/29/2016
Research Description
Research is focused on mechanisms of inherited retinal degeneration and neuroprotection. His most recent studies have shown the important contribution of endogenously expressed cytokines such as leukemia inhibitory factor (LIF)
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Last Updated
6/3/2016
Research Description
Functional genomics; gene expression profiling using DNA microarrays to understand phenotype.Developing gene expression classifiers of prognostic value.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Last Updated
6/1/2016 11:01:32 AM
Research Description
The focus of the lab is on the molecular basis of pathogenesis of the herpesviruses and the application of these concepts and control of latent gene expression. Specifically we have recently been investigating the role of HSV non-coding RNAs on the regula
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
Yes
Last Updated
6/7/2016 2:02:48 PM
Research Description
Biochemistry of DNA replication and repair; dynamic protein DNA interactions and enzyme mechanisms required for these processes.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Last Updated
5/31/2016 12:51:04 PM
Research Description
My lab uses transgenic & knockout mouse models, and cell models, to determine molecular mechanisms by which mutations in specific genes cause familial neurodegenerative diseases - primarily Alzheimer's disease and amyotrophic lateral sclerosis.
Department:
Ophthalmology
Concentrations:
Accepting Students
Yes
Last Updated
1/13/2017 4:25:37 PM
Research Description
Optimizing gene therapy vectors (AAV) for the treatment of inherited retinal disease.
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
The overarching focus of our work is the study of how cells maintain genomic homeostasis and how alterations in the genome and epigenome impact the process of tumorigenesis. At present, our work is focused on two projects: Our first project delves into
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Last Updated
6/1/2016 9:21:19 AM
Research Description
Analysis of long distance gene regulation by enhancers and locus control region. Genomic and proteomic analysis of erythroid transcription factors. Modulation of gene expression using synthetic zinc finger proteins.
Department:
Pediatrics
Concentrations:
Accepting Students
No
Last Updated
5/25/2016
Research Description
Cardiovascular gene therapy; adeno-associated viral vectors.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Last Updated
5/23/2016 12:04:53 PM
Research Description
Development of novel gene transfer tools, small animal models for the study of HIV and cancer, vaccines and immuno-therapeutic strategies for these diseases.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Last Updated
6/10/2016
Research Description
Development of genitourinary system; Developmental mechanisms of morphological evolution; genetic and environmental causes of birth defects
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Last Updated
5/24/2016 3:49:35 PM
Research Description
Research focuses on complex genetic disorders and gene-environment interactions, and includes studies of radiation sensitivity, breast cancer, and type 1 diabetes
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
Innate and acquired immune mechanisms in the pathogenesis of kidney disease: chronic allograft mephropathy, diabetes and lupus nephritis.
Department:
Infectious Diseases and Pathology
Concentrations:
Accepting Students
Yes
Last Updated
5/23/2016
Research Description
Department:
Pediatrics
Concentrations:
Accepting Students
No
Last Updated
6/1/2016 3:11:55 PM
Research Description
The phenomenon of genomic imprinting is the differential modification of the maternal and paternal genetic contributions to the zygote, resulting in the differential expression of parental alleles during development and in the adult. A disturbance in genomic imprinting can lead to various genetic diseases including Prader-Willi syndrome (PWS). Besides serving as a model for imprinting, PWS is a great model to understand obesity which is a hallmark feature of this condition.
Department:
Surgery
Concentrations:
Accepting Students
Yes
Last Updated
5/31/2016
Research Description
Dr. Efron has a professional interest in surgical critical care and trauma, both clinically as well as in the laboratory. He conducts basic science and translational research in sepsis and inflammation. He is currently one of the principal investigators for an NIH-funded P50 center grant for the UF Sepsis and Critical Illness Research Center to study the persistent inflammation, immunosuppression and catabolism syndrome (PICS) following sepsis in surgical intensive care unit patients. He also has his own NIH R01 funding regarding examining the hematopoietic response of the elderly to severe trauma. He was mentored by and now collaborates with Drs. Moldawer, Baker and Leeuwenburgh.
Department:
Pediatrics
Concentrations:
Accepting Students
No
Last Updated
6/29/2016 1:08:37 PM
Research Description
Effect of immunosuppression on anti-GAA antibody development in patients with Pompe disease, clinical trial studies as part of CARRA (Childhood Arthritis and Rheumatology Research Alliance)
Department:
Orthopaedics & Rehabilitation
Concentrations:
Accepting Students
No
Last Updated
5/23/2016
Research Description
Gene delivery approaches to the treatment and repair of musculoskeletal disorders including osteoarthritis and cancer.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Last Updated
5/23/2016 12:53:49 PM
Research Description
We use molecular genetics and genomics coupled with animal models to examine how a normal intestinal bacterium, Oxalobacter formigenes, helps prevent kidney stones. We also use genetics and animal models to examine pathogenesis of disease caused by Vibrio vulnificus.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Last Updated
5/23/2016 1:17:46 PM
Research Description
Molecular pathways of embryonic development; vertebrate model systems of limb development; invertebral disk formation & disease using mouse models.
Department:
Ophthalmology
Concentrations:
Accepting Students
No
Last Updated
5/23/2016 12:20:14 PM
Research Description
Gene expression, and gene delivery, gene therapy and functional genomics in the retina.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Last Updated
5/24/2016
Research Description
My research focus is in DNA double-strand break (DSB) repair. We have isolated and characterized several novel components of DNA DSB repair, such as Metnase and EEPD1, that cancer cells use to resist chemotherapy. By targeting these repair components we can restore the sensitivity of some resistant cancers to chemotherapy.
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
Yes
Last Updated
6/1/2016
Research Description
Chromatin structure and gene regulation; Epigenetic regulation of stem cell function and hematopoiesis; Structure and function of chromatin insulator.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Last Updated
5/24/2016 1:37:13 PM
Research Description
Molecular mechanisms of host-pathogen interactions; virulence mechanism of Pseudomonas aeruginosa infection and development of antimicrobial strategies; Cellular reprogramming and genome editing
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Last Updated
6/11/2015 4:54:16 PM
Research Description
Pathogenesis of noroviruses, innate immune responses to norovirus infection, and molecular mechanisms of norovirus replication. Mucosal immunity to, and pathogenesis, of murine norovirus infection.
Department:
Medicine
Concentrations:
Accepting Students
No
Last Updated
6/1/2016
Research Description
Molecular basis for human cancer and the clinical management of patients with thoracic malignancies.
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Last Updated
6/1/2016 1:12:45 PM
Research Description
Our research program has three major areas of interest that focus on the influence of nutrient stress on gene expression. For the first project, we investigate the regulation of pre-mRNA alternative splicing of the transcription factor ATF3 which has bee
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
Yes
Last Updated
7/18/2016 9:44:16 AM
Research Description
Mammalian cell culture systems Epigenetic regulation of transcription; chromatin structure and function; epigenetic silencing of tumor suppressor genes in cancer; single-molecule analysis of chromatin structure
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Last Updated
5/23/2016 12:06:25 PM
Research Description
Dr. Lewin's current research involves the development of gene and pharmacological therapies for neurodegenerative diseases of the retina and the central nervous system. The group has developed a mouse model of Age Related Macular Degeneration, a common blinding disease of the elderly.

Mark Q. Martindale, Ph.D.

Department:
Whitney Laboratories
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
Director of the Whitney Laboratory for Marine Bioscience and renowned scientist. His research focus is aimed at elucidating the cellular and molecular basis for the evolution of cell-type complexity.
Department:
Environmental Health
Concentrations:
Accepting Students
Yes
Last Updated
5/25/2016 12:22:13 PM
Research Description
Pathogenic mechanisms of Shigella and Chlamydia Evolution and emergence of Shiga toxin-producing Shigella flexneri Cell wall metabolism and cell division processes of Chlamydia spp. Surveillance of non-HIV sexually transmitted infections in Haiti Laboratory capacity building
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Last Updated
6/3/2016 1:48:54 PM
Research Description
Genetics of susceptibility to autoimmune disease, vitiligo, education research.

Peter McFetridge, Ph.D.

Department:
Biomedical Engineering
Concentrations:
Accepting Students
No
Last Updated
5/24/2016 11:46:34 AM
Research Description
Vascular remodeling, wound healing and tissue engineering (vascular/bone/cartilage)
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Last Updated
5/31/2016 9:35:24 AM
Research Description
Focused on the use of statistical ltheory to elucidate the relationship between genotype and phenotype. Currently interested in simple models for gene networks.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
Yes
Last Updated
5/24/2016 1:55:29 PM
Research Description
Genetic analysis of systemic lupus erythematosus (SLE) susceptibility using mouse models, immune metabolism and use of metabolic inhibitors to treat lupus Microbiome and lupus
Department:
Whitney Laboratories
Concentrations:
Accepting Students
Yes
Last Updated
6/6/2016 11:50:20 AM
Research Description
Genomic Bases of Memory and Neuronal Evolution. Our laboratory works to characterize basic mechanisms underlying the design of nervous systems and evolution of neuronal signaling mechanisms. The major questions are: (1) why are individual neurons so different? (2) How do learning and memory store in neuronal genomes and neural circuits? (3) How to restore memories? (4) How to make a neuron and a brain?
Department:
Medicine
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
Molecular epidemiology and transmission modeling of Vibrio cholerae in Haiti and Bangladesh.
Department:
Medicine
Concentrations:
Accepting Students
No
Last Updated
5/31/2016 11:18:50 AM
Research Description
Treatments for disorders that affect mitochondrial function.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Last Updated
11/12/2015 11:27:22 AM
Research Description
Uses human genetics studies to define the molecular causes of neurological and neuromuscular disease and animal models to understand how disease-causing mutations affect neuronal function.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Last Updated
5/23/2016 12:19:16 PM
Research Description
Biology of Kaposi's sarcoma-associated herpesvirus (KSHV); role of latency-associated nuclear antigen (LANA) in transcriptional regulation, viral DNA replication, and episomal segregation in latently-infected cells; role of virus-encoded micro RNAs.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Last Updated
5/23/2016
Research Description
Genetic imprinting mechanisms and mouse models of imprinting disorders. Epigenetic reprogramming during germ cell development.
Department:
Pediatrics
Concentrations:
Accepting Students
No
Last Updated
Research Description
Dr. Rivkees developed a research program that is focused in three major areas: circadian biology, adenosinergic influences on brain injury of prematurity and the discovery of novel pediatric diagnostics and therapeutics. He discovered that the biological clock of preterm infants is responsive to low intensity lighting, leading to new treatment practices for preterm infants. He discovered that A1 adenosine receptor activation induces periventricular white matter injury (PWMI)-the most common neurological disorder affecting premature infants. He has recently discovered adverse effects on body composition and heart function related to prenatal caffeine exposure, findings reported widely in the press. Recently, he started a new research program aimed at the development of novel pediatric diagnostics and therapeutics. Most recently the Rivkees laboratory has begun to focus on the risks and adverse events associated with Graves’ disease therapy in children and during pregnancy.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Last Updated
6/1/2015 3:28:47 PM
Research Description
Molecular evolution of viruses, with special emphasis on HIV and SIV. Development and application of new bioinformatics and phylogenetic analysis tools to investigate the Molecular epidemiology of viral and bacterial pathogens, with emphasis on Vibrio cholerae, MRSA and Neisseria meningiditis
Department:
Pediatrics
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
Prediction, immunopathogenesis, genetics and prevention and care of Type 1 diabetes.
Department:
Obstetrics & Gynecology
Concentrations:
Accepting Students
No
Last Updated
6/1/2016 1:24:23 PM
Research Description
Role of growth factors and proteases in ocular and skin wound healing; gene therapy using ribozymes to receptors.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Last Updated
6/1/2016 3:26:11 PM
Research Description
Molecular Genetics and Biology of Pathogenic Bacteria; Drug Resistance
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Last Updated
5/23/2016 9:19:26 AM
Research Description
My laboratory works on the fundamental biology of stem cells. Our goal is to design test and bring new cell based therapies to the clinic. How stem cells are involved in cancer and the creation of a supportive "cancer niche" are two primary areas of res
Department:
Whitney Laboratories
Concentrations:
Accepting Students
Yes
Last Updated
6/10/2016 12:57:21 PM
Research Description
Research focus:the cellular and molecular mechanisms of development and regeneration in annelids and other closely related marine animals. Interests: patterning of embryonic stem cells, neurogenesis, regenerative biology and patterning of the germline.
Department:
Periodontology
Concentrations:
Accepting Students
No
Last Updated
6/13/2016 11:02:57 AM
Research Description
Shaddox main research study, funded by the National Institutes of Health, is aimed at evaluating immunological, microbiological and genetic factors involved with localized aggressive periodontal disease. This is a rare type of gum disease affecting mostly young children and adolescents
Department:
Entomology & Nematology
Concentrations:
Accepting Students
No
Last Updated
5/25/2016
Research Description
Genetic transformation of the obligate intracellular bacterium, Wolbachia, and it's use in paratransgenic introgression of genetic elements in insects.
Department:
Pediatrics
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
Leukemia remains the number one cause of cancer related death in children. Our laboratory focuses on developing improved therapies for childhood leukemia by targeting leukemia cell interaction with the microenvironment. The lab has basic projects fo
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Last Updated
6/9/2015 1:00:13 PM
Research Description
Molecular aspects of adeno-associated virus maintence in vivo, viral gene transfer vectors.
Department:
Medicine
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
Mechanisms of autoantibody production.
Department:
Pediatrics
Concentrations:
Accepting Students
Yes
Last Updated
6/2/2015 10:07:38 AM
Research Description
For the past 35 years, Dr. Srivastava’s research has been focused on the following two parvoviruses, the non-pathogenic adeno-associated virus (AAV), and a common human pathogen, the parvovirus B19, and the development of recombinant parvovirus vectors in human gene therapy. His laboratory has made seminal contributions to the field of parvoviruses, which include: identification of cellular co-receptors for AAV2 [A] and AAV3 [B] as well as parvovirus B19 [C]; elucidation of various steps involved in parvovirus trafficking in the cell and nuclear transport; identification of cellular proteins involved in the regulation of AAV DNA replication and encapsidation; development of recombinant AAV and parvovirus B19 vectors; and transgenic and knockout mouse models to study parvovirus-induced pathogenicity, and the use of parvovirus vectors for gene transfer and gene therapy. Recently, his laboratory has developed the next generation (“NextGen”) AAV vectors [D] in which the viral capsid has been modified to achieve high-efficiency transduction at significantly reduced vector doses. More recently, his laboratory has also modified the AAV genome to develop the generation X (“GenX”) AAV vectors [E] with which increased transgene expression can be achieved. The NextGen AAV vectors are currently being used by other investigators in a Phase I Clinical Trial for Leber's Hereditary Optic Neuropathy (LHON). Two additional Phase I Clinical Trials using NextGen AAV vectors (X-linked retinoschisis and Achromatopsia), sponsored by a biotechnology company, are planned to be initiated in 2015. The NextGen and the GenX vectors are being combined in Dr. Srivastava’s laboratory to develop the optimized [“Opt”] AAV serotype vectors, and the current emphasis is on the potential gene therapy of genetic diseases such as ß-thalassemia and sickle cell disease, and malignant disorders such as hepatoblastoma and hepatocellular carcinoma.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Last Updated
6/3/2016 11:19:18 AM
Research Description
Mouse models for neurological disease;RNA processing, transport and turnover; molecular mechanisms of mammalian development and aging
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Last Updated
6/13/2016 9:14:06 AM
Research Description
Pathogenesis of oncogenic viruses, virus-host interactions, host immunity to viruses, viral latency, viral noncoding RNAs.
Department:
Oral Biology
Concentrations:
Accepting Students
Yes
Last Updated
8/18/2016
Research Description
Pathogenesis of oncogenic herpesviruses, mechanisms of viral immune evasion, epigenetic regulation of gammaherpesvirus infection, viral genetics
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Last Updated
5/24/2016
Research Description
Mapping, cloning, mutation and functional analysis of human disease genes.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Last Updated
6/3/2016
Research Description
Our current research falls within the general themes of host-pathogen interactions, and is divided into two major areas 1) Molecular studies of HIV and HCV pathogenesis and drug resistance and 2) Ecology of indigenous microbial communities associated with human infections
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Last Updated
6/1/2016
Research Description
We study microsatellite repeat expansion diseases, including myotonic dystrophy. We use molecular, cellular, computational, and animal-based approaches to understand basic mechanisms that cause symptoms in this and related multi-systemic diseases, as well as identify treatments that will help patients. We also study RNA localization at a basic level, to understand why and how RNA molecules move to different places in the cell. We seek to combine high-throughput genomics approaches with single molecule imaging approaches to characterize and understand this new frontier in biology.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Last Updated
6/3/2016 8:49:14 AM
Research Description
We are studying cancer cell signaling with expertise in signal transduction, genetic and epigenetic regulation, and animal models. Our current laboratory research is centered on two families of transcriptional co-activators, MAML and CRTC, which are essential components of Notch receptor signaling and LKB1-CRTC/CREB signaling pathways, respectively. We are investigating the molecular regulation and the roles of deregulated cell signaling in cancer generation and progression, with the goal of gaining molecular insights into cancer pathogenesis and identifying novel cancer diagnostic and therapeutic targets.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Last Updated
6/10/2016
Research Description
General Neuropathology. Neurodegenerative diseases.
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
Our lab studies the epigenetic regulation of transcription in mammals. We are interested specfically in mechanisms of epigenetic regulation by genomic imprinting in the Angelman/Prader-Willi syndrome region of human chromosome 15 (and mouse chromosome 7
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Last Updated
6/10/2016
Research Description
Epigenetic regulation of stress-induced apoptosis. Role of pro-apoptotic response in innate immunity against virus infection. Modeling apopotosis following treatment of chemotherapeutic drugs.

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