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Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
Yes
Last Updated
6/7/2016 2:02:48 PM
Research Description
Biochemistry of DNA replication and repair; dynamic protein DNA interactions and enzyme mechanisms required for these processes.
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
The overarching focus of our work is the study of how cells maintain genomic homeostasis and how alterations in the genome and epigenome impact the process of tumorigenesis. At present, our work is focused on two projects: Our first project delves into
Department:
Medicine
Concentrations:
Accepting Students
Yes
Last Updated
5/31/2016
Research Description
Characterize the immune suppressor mehanisms involved in the develeopment of HCC in the background of cirrhosis to identify novel targets that can lead to development of new immune activating strategies and/or prognostic and predictive immune biomarkers.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
No
Last Updated
5/24/2016 12:07:02 PM
Research Description
My laboratory is examining mechanisms for loss of human beta cells in type 1 diabetes and ways to restore functional beta cell mass. Studies will be conducted using human samples obtained through the Network for Pancreatic Organ Donors with Diabetes (nPOD) and isolated human islets or cell lines.
Department:
Oral Surgery
Concentrations:
Accepting Students
No
Last Updated
5/23/2016 1:01:02 PM
Research Description
Molecular processes that lead to the establishment of chronic pain; alterations in function of the N-Methyl-D-Aspartate (NMDA) receptor and vanilloid receptor as a result of persistent peripheral stimulation.
Department:
Oral Biology
Concentrations:
Accepting Students
No
Last Updated
5/23/2016 1:09:57 PM
Research Description
The current research projects are 1) studies of microRNAs in the regulation of toll-like receptor signaling pathways in innate immune response and their relationship to autoimmune diseases, including rheumatoid arthritis and systemic lupus erythematosus and periodontal disease; 2) microRNAs in oral cancer as biomarkers and targets for therapy; 3) biological function of subcellular rod/ring structures
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Last Updated
5/23/2016 12:04:53 PM
Research Description
Development of novel gene transfer tools, small animal models for the study of HIV and cancer, vaccines and immuno-therapeutic strategies for these diseases.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Last Updated
5/23/2016 2:58:49 PM
Research Description
The Cogle Research Group is focused on clinical and laboratory research in stem cells and cancer. Projects include: (a) identification of novel agents & pathways for treatment of blood cancers, (b) using genomics to understand origins of blood cancers, (c) using genomics to understand drug response, discover new biomarkers and identify new drugs for treatment of patients with blood cancers.
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
Yes
Last Updated
5/23/2016
Research Description
Mitogenic signaling by G protein-coupled receptors; vesicle trafficking.
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Last Updated
6/1/2016 9:03:36 AM
Research Description
Over the last five years, my lab has explored the function of carbonic anhydrase IX (CAIX) expression and activity in breast cancer. We hypothesize that CAIX is involved in regulating extracellular pH to the advantage of tumor cells. This is a particula
Department:
Orthopaedics & Rehabilitation
Concentrations:
Accepting Students
No
Last Updated
5/23/2016
Research Description
Gene delivery approaches to the treatment and repair of musculoskeletal disorders including osteoarthritis and cancer.
Department:
Neuroscience
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
Pathogenesis and treatment of Alzheimers and other Neurodegenerative disease

Olga Guryanova, M.D., Ph.D.

Department:
Pharmacology & Therapeutics
Concentrations:
Accepting Students
Yes
Last Updated
9/13/2016
Research Description
My overall research and career objectiveis to lead a translational cancer research team focusing on molecular pathogenesis and mechanisms of therapeutic resistance in hematologic malignancies. Specifically, my research program is aimed at elucidating the role of mutations in DNMT3A and other epigenetic modifier genes in altered chromatin dynamics and suboptimal response to chemotherapy, that contribute to inferior prognosis in acute my eloid leukemia (AML). Thanks to my vast expertise in genetic mouse modeling and molecular cell biology, combined with innovative tools and nterdisciplinary approaches, I am uniquely positioned to gain novel insights into the molecular mechanisms governing normal and leukemic hematopoiesis and to identify actionable targets for cancer therapy
Department:
Pharmacology & Therapeutics
Concentrations:
Accepting Students
Yes
Last Updated
6/1/2016 2:00:38 PM
Research Description
Neuroimmunopharmacology. Chemokines and chemokine receptors in brain tumors. Focus on glioblastoma and pharmacological targeting using pre-clinical animal models
Department:
Medicine
Concentrations:
Accepting Students
No
Last Updated
5/24/2016 1:44:54 PM
Research Description
Gene and stem cell therapies
Department:
Medicine
Concentrations:
Accepting Students
Yes
Last Updated
5/24/2016
Research Description
My research focus is in DNA double-strand break (DSB) repair. We have isolated and characterized several novel components of DNA DSB repair, such as Metnase and EEPD1, that cancer cells use to resist chemotherapy. By targeting these repair components we can restore the sensitivity of some resistant cancers to chemotherapy.
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
Yes
Last Updated
6/1/2016 9:52:19 AM
Research Description
Chemoresistance in breast and prostate cancer, Nuclear Structure and Function, Epigenetic Regulation of Gene Expression tumor Suppression
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Last Updated
5/24/2016 1:37:13 PM
Research Description
Molecular mechanisms of host-pathogen interactions; virulence mechanism of Pseudomonas aeruginosa infection and development of antimicrobial strategies; Cellular reprogramming and genome editing
Department:
Medicine
Concentrations:
Accepting Students
No
Last Updated
6/1/2016
Research Description
Dr. Jobin is interested in bacteria/host interactions and ensuring innate/immunological responses during health and diseases. The intestine poses an interesting conundrum – it must peacefully cohabit with a sea of commensal bacteria (~100 trillion) and a high load of bacterial products, but swiftly respond to the presence of pathogenic micro-organisms that threaten its integrity. A major clinical consequence of deregulated bacteria/host interaction in the intestine is the development of inflammatory bowel diseases (IBD) and colorectal cancer. Using mice and zebrafish housed in germ-free and gnotobiotic conditions, microbiome techniques (next-generation sequencing, microbial gene mutations, microbial RNA-sequence, etc.), Dr. Jobin studies the differential contribution of bacteria in protecting or exacerbating development of colitis and colorectal cancer. Dr. Jobin has contributed to the understanding of the cellular and molecular mechanism regulating host response to bacterial colonization, and has published numerous papers on innate signaling events taking place in the intestine and how these impact intestinal homeostasis.
Department:
Physical Therapy
Concentrations:
Accepting Students
Yes
Last Updated
5/23/2016 1:31:54 PM
Research Description
Exploration of the molecular mechanisms that cause cancer-associated skeletal muscle wasting and weakness, using cell based models, rodent models and patient biopsies
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
Yes
Last Updated
7/18/2016 9:44:16 AM
Research Description
Mammalian cell culture systems Epigenetic regulation of transcription; chromatin structure and function; epigenetic silencing of tumor suppressor genes in cancer; single-molecule analysis of chromatin structure
Department:
Pharmacology & Therapeutics
Concentrations:
Accepting Students
No
Last Updated
5/23/2016 1:13:18 PM
Research Description
Our research focuses on the roles of the CDCP1 protein and the TGF-beta and mTORC1 signaling pathways in breast cancer invasion and metastasis. Our overall goal is to develop innovative and effective drugs for the treatment of human cancers.
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
Yes
Last Updated
5/31/2016 1:15:25 PM
Research Description
We study roles of lysine acetyltransferases (KATs) and deacetylases (HDACs) in cancer cell biology and virology. We are also interested in discovering and optimizing small-molecule inhibitors of these enzymes for cancer therapy.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Last Updated
6/10/2016
Research Description
Jonathan D. Licht, MD, is the Director of the University of Florida Health Cancer Center, holding the Marshall E. Rinker, Sr. Foundation and David B. and Leighan R. Rinker Chair. Dr. Licht's laboratory studies aberrant gene regulation as a cause of blood cancers, specifically the role of abnormal function of histone methyl transferases and histone demethyalses in diseases such as multiple myeloma, lymphoma and acute lymphocytic leukemia, and is developing small molecule strategies to revert abnormal gene regulation and treat disease.
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
No
Last Updated
5/24/2016 1:10:27 PM
Research Description
Epigenetic and metabolic regulation of tumor progression.
Department:
Medicinal Chemistry
Concentrations:
Accepting Students
No
Last Updated
5/24/2016
Research Description
Dr. Luesch’s multidisciplinary research program at the interface of chemistry and biology combines classical natural products chemistry with high-throughput screening and chemical genomics. It involves most aspects of drug discovery ranging from the collection of promising marine organisms, bioassay development, NMR spectroscopic structure determination, total synthesis, mechanism-of-action studies, and pharmacology, up to the preclinical and clinical development of candidate molecules. His lab is producing a small but increasing pipeline of bioactive compounds that are at various developmental stages. He also uses functional genomics approaches to identify and characterize genes associated with disease processes, especially cancer and neurological disorders.
Department:
Infectious Diseases and Pathology
Concentrations:
Accepting Students
No
Last Updated
5/24/2016 11:07:30 AM
Research Description
Retrovirus vector for gene transfer based on foamy virus. Comparative and experimental pathology.
Department:
Neurosurgery
Concentrations:
Accepting Students
No
Last Updated
6/22/2015
Research Description
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
No
Last Updated
5/31/2016 12:49:46 PM
Research Description
Role of tumor suppressor APC in initiation & progression of colorectal cancer; transcriptional regulation of APC gene & its role in breast carcinogenesis; mechanisms of secondhand smoking-induced lung and breast carcinogenesis; Targeting ATR/Chk1 pathway for therapeutic development of colorectal cancer.
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
Yes
Last Updated
6/10/2016 2:17:26 PM
Research Description
Immunological regulation by T cells; structural interactions between ligand pairs linked to T cell interaction as defined by X-ray crystallography and functional studies.
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
No
Last Updated
6/10/2016 1:46:35 PM
Research Description
Structure and function of Histone deacetylases, and their roles in gene regulation and cancer.
Department:
Neurosurgery
Concentrations:
Accepting Students
No
Last Updated
6/1/2016 3:42:28 PM
Research Description
Characterization and manipulation of adult neural stem cells.
Department:
Pharmacology & Therapeutics
Concentrations:
Accepting Students
No
Last Updated
6/10/2016
Research Description
Topoisomerases; cancer and microbial chemotherapy; mitochondrial DNA; chromatin structure. Malaria, plastid/organellar DNA and anti-malarial drugs.
Department:
Physiology & Functional Genomics
Concentrations:
Accepting Students
No
Last Updated
5/23/2016 2:06:21 PM
Research Description
Cellular and biochemical mechanisms by which G protein-coupled receptors activate physiologically important tyrosine kinase signaling pathways.
Department:
Pharmaceutics
Concentrations:
  • Cancer Biology
Accepting Students
Yes
Last Updated
8/29/2016
Research Description
Dr, Schmittgen's research focuses on noncoding RNAs and cancer, with emphasis on the use of microRNAs as therapeutic or diagnostic agents. A paper he co-authored in 2001 describing the relative method of gene quantification has been cited over 36,000 times and was recently ranked by the international journal Nature as the 21st most-cited scientific article of all time. His lab was the first to establish a link between altered microRNA expression in pancreatic cancer and the intellectual property resulting from this work is the basis of the product miRInform Pancreas™, a biomarker of early pancreatic cancer development. Recently, he has focused his attention on the development of microvesicles as targeted drug delivery systems for the treatment of cancer.
Department:
Radiation Oncology
Concentrations:
Accepting Students
Yes
Last Updated
6/13/2016 2:11:20 PM
Research Description
Our research laboratory seeks to improve cancer therapies through molecular targeting strategies and physiologic interventions such as exercise. A primary focus is the tumor microenvironment which not only influences treatment resistance of cancer to conventional anticancer therapies but also plays a critical role in neoplastic cell initiation, malignant progression, and metastatic spread to secondary sites.
Department:
Chemistry
Concentrations:
Accepting Students
No
Last Updated
6/10/2016 2:04:06 PM
Research Description
Molecular Medicine; Nanomedicine; Chemical Biology; Bioanalytical chemistry; Biomedical Engineering
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Last Updated
6/13/2016 9:14:06 AM
Research Description
Pathogenesis of oncogenic viruses, virus-host interactions, host immunity to viruses, viral latency, viral noncoding RNAs.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Last Updated
5/24/2016
Research Description
Mapping, cloning, mutation and functional analysis of human disease genes.
Department:
Oral Biology
Concentrations:
Accepting Students
No
Last Updated
6/1/2016 3:22:14 PM
Research Description
The major focus of my research program is dedicated to the understanding of homeostatic mechanisms which are disrupted in autoimmunity, inflammatory diseases and cancer processes. I have investigated regulatory mechanisms ranging from those associated with the adaptive immune response [regulatory T cells and dendritic cells] and innate immune responses [monocytes, macrophages and neutrophils] to those associated with mucosal homeostasis [epithelial cell immune responses]. In short, I spent my formal training deciphering the lack of regulatory responses in type 1 diabetes (T1D) using the non-obese diabetic (NOD) mouse model; developing therapies to improve this phenomenon; and finally evaluating mechanisms of therapeutic efficacy (or lack thereof). In recent years, I have focused my research on the role of epithelial and stromal cells in innate immune responses and how these non-traditional innate mediators contribute to immune tolerance, systemic immunity, and cancer progression.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Last Updated
6/3/2016 8:49:14 AM
Research Description
We are studying cancer cell signaling with expertise in signal transduction, genetic and epigenetic regulation, and animal models. Our current laboratory research is centered on two families of transcriptional co-activators, MAML and CRTC, which are essential components of Notch receptor signaling and LKB1-CRTC/CREB signaling pathways, respectively. We are investigating the molecular regulation and the roles of deregulated cell signaling in cancer generation and progression, with the goal of gaining molecular insights into cancer pathogenesis and identifying novel cancer diagnostic and therapeutic targets.
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
Yes
Last Updated
5/24/2016 11:49:55 AM
Research Description
Mechanism of oncogenic transformation. Cooperation of oncogenes and suppressor genes in cancer development. Genetically engineered mice models for cancer. Targeted therapeutics in pancreatic and lung cancer models.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
No
Last Updated
6/10/2016
Research Description
Epigenetic regulation of stress-induced apoptosis. Role of pro-apoptotic response in innate immunity against virus infection. Modeling apopotosis following treatment of chemotherapeutic drugs.

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