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Department:
Medicine
Concentrations:
Accepting Students
Yes
Last Updated
6/10/2016 9:11:54 AM
Research Description
Cell biology and biochemistry of actin-binding proteins involved in apoptosis, angiogenesis, neural plasticity and cancer biology.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Last Updated
5/31/2016
Research Description
Characterize the immune suppressor mehanisms involved in the develeopment of HCC in the background of cirrhosis to identify novel targets that can lead to development of new immune activating strategies and/or prognostic and predictive immune biomarkers.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Last Updated
10/12/2016
Research Description
Department:
Medicine
Concentrations:
Accepting Students
Yes
Last Updated
5/23/2016 2:58:49 PM
Research Description
The Cogle Research Group is focused on clinical and laboratory research in stem cells and cancer. Projects include: (a) identification of novel agents & pathways for treatment of blood cancers, (b) using genomics to understand origins of blood cancers, (c) using genomics to understand drug response, discover new biomarkers and identify new drugs for treatment of patients with blood cancers.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Last Updated
6/10/2016
Research Description
Development of genitourinary system; Developmental mechanisms of morphological evolution; genetic and environmental causes of birth defects
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
Yes
Last Updated
5/23/2016
Research Description
Mitogenic signaling by G protein-coupled receptors; vesicle trafficking.
Department:
Vet Med- Research
Concentrations:
Accepting Students
Yes
Last Updated
12/6/2016
Research Description
Discovery of novel interventions in the fight against malaria requires a pioneering approach to examine cell-cell interactions among the transmission stages of the parasite (i.e., sporozoite and ookinete) and their respective mammalian or mosquito host cells. Glycobiology offers such a unique approach. In model systems, glycans and glycoconjugates have been shown to be important structural components of cell walls and the extracellular matrix, modifiers of protein solubility (secretion) and stability (protection from enzyme degradation), modulators of glycoprotein trafficking both intra- and extracellularly (e.g., by modifying porosity of the glycocalyx), mediators of cell-cell and cell-matrix adhesion and intra- and extracellular signaling. Yet, despite their clear importance in cell biology, an appreciation of glycan posttranslational modification of critical proteins involved in host-pathogen interactions, especially in the context of malaria parasite development, remains undervalued.
Department:
Surgery
Concentrations:
Accepting Students
Yes
Last Updated
5/31/2016
Research Description
Dr. Efron has a professional interest in surgical critical care and trauma, both clinically as well as in the laboratory. He conducts basic science and translational research in sepsis and inflammation. He is currently one of the principal investigators for an NIH-funded P50 center grant for the UF Sepsis and Critical Illness Research Center to study the persistent inflammation, immunosuppression and catabolism syndrome (PICS) following sepsis in surgical intensive care unit patients. He also has his own NIH R01 funding regarding examining the hematopoietic response of the elderly to severe trauma. He was mentored by and now collaborates with Drs. Moldawer, Baker and Leeuwenburgh.
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
Yes
Last Updated
6/10/2016
Research Description
Research in the Huang lab is concentrated on elucidating molecular mechanisms associated with breast and ovarian cancer metastasis. One of the current projects is to investigate how homeobox domain-containing proteins SHOX2 and HOXC8 regulate breast cancer metastasis with the focus on their role in epithelial-mesenchymal transition (EMT). Another project is based on our early discovery that the integrity of EPS8/ABI1/SOS1 tri-complex is critical for ovarian cancer metastasis. In this project, we are currently dissecting the players and pathways pertinent to the metastasis-promoting role of EPS8/ABI1/SOS1 tri-complex in ovarian cancer. In addition, the Huang lab is also working on identifying cancer driver genes/pathways in ovarian cancer, with the emphasis on developing targeted therapeutic strategies against ovary malignancies.
Department:
Biochemistry & Molecular Biology
Concentrations:
Accepting Students
Yes
Last Updated
6/1/2016
Research Description
Chromatin structure and gene regulation; Epigenetic regulation of stem cell function and hematopoiesis; Structure and function of chromatin insulator.
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
Yes
Last Updated
6/1/2016 9:52:19 AM
Research Description
Chemoresistance in breast and prostate cancer, Nuclear Structure and Function, Epigenetic Regulation of Gene Expression tumor Suppression

Richard J. Johnson, M.D.

Department:
Medicine
Concentrations:
Accepting Students
Yes
Last Updated
6/22/2015
Research Description
Mechanisms of renal injury and progression, including in glomerulonephritis, diabetes, and hypertension.
Department:
Physiology & Functional Genomics
Concentrations:
Accepting Students
Yes
Last Updated
5/24/2016 10:13:40 AM
Research Description
Our current research interest is to understand the function of Nkx2.5, an evolutionarily conserved NK2 class of homeobox transcription factor in mature cardiomyocytes. Within the genomic analysis of cardiovascular diseases, mutations of NKX2.5 (capitals
Department:
Surgery
Concentrations:
Accepting Students
Yes
Last Updated
5/23/2016 9:47:50 AM
Research Description
Mitochondrial autophagy. Mitochondrial dysfunction in ischemia/reperfusion injury to liver, liver aging and hepatotoxicity.
Department:
Aging & Geriatrics Research
Concentrations:
Accepting Students
Yes
Last Updated
5/24/2016 2:26:46 PM
Research Description
Physiology, biology & biochemistry of aging, with focus on MITOCHONDRIAL BIOLOGY, AUTOPHAGY, apoptosis and oxidative stress. Aging, oxidative stress, MITOCHONDRIA, AUTOPHAGY apoptosis, ant-aging interventIONS.
Department:
Chemical Engineering
Concentrations:
Accepting Students
Yes
Last Updated
12/6/2016
Research Description
Dr. Lele’s research is in the area of mechanobiology. We are interested in the mechanisms by which mechanical stresses on the nucleus impact gene expression in health and disease. The lab combines cutting edge microscope techniques, biophysical assays, genomics and molecular biology approaches to address hypotheses. Current collaborations are with Jonathan Licht (Director of Cancer Center), Jeffrey Nickerson (Anatomy and Cell Biology, U Mass medical school), Kyle Roux (Sanford Research), Richard Dickinson (UF Che) and Gregg Gundersen (Cell Biology, Columbia University). The lab has NIH-funded openings for PhD students.
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
Yes
Last Updated
5/31/2016 1:15:25 PM
Research Description
We study roles of lysine acetyltransferases (KATs) and deacetylases (HDACs) in cancer cell biology and virology. We are also interested in discovering and optimizing small-molecule inhibitors of these enzymes for cancer therapy.
Department:
Neuroscience
Concentrations:
Accepting Students
Yes
Last Updated
6/1/2016 3:02:22 PM
Research Description
Studies on the cellular and molecular bases for inherited peripheral neuropathies and approaches to attenuate the accumulation of misfolded proteins within cells. Schwann cell biology, myelin formation, small molecule therapies and dietary approaches
Department:
Medicine
Concentrations:
Accepting Students
Yes
Last Updated
8/11/2016 9:49:27 AM
Research Description
Obesity and metabolic syndrome: inflammatory and prodiabetic effects of hyperuricemia and underlying signaling mechanisms responsible for these effects; role of ketohexokinase in the pathogenesis of obesity and the metabolic syndrome; molecular signaling
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Last Updated
5/23/2016 9:19:26 AM
Research Description
My laboratory works on the fundamental biology of stem cells. Our goal is to design test and bring new cell based therapies to the clinic. How stem cells are involved in cancer and the creation of a supportive "cancer niche" are two primary areas of res
Department:
Whitney Laboratories
Concentrations:
Accepting Students
Yes
Last Updated
6/10/2016 12:57:21 PM
Research Description
Research focus:the cellular and molecular mechanisms of development and regeneration in annelids and other closely related marine animals. Interests: patterning of embryonic stem cells, neurogenesis, regenerative biology and patterning of the germline.
Department:
Medicine
Concentrations:
Accepting Students
Yes
Last Updated
5/24/2016
Research Description
Novel techniques to determine endothelial health. Use of circulating endothelial cell and endothelial progenitor cells to evaluate the risk of future atherosclerosis and end-organ damage.
Department:
Aging & Geriatrics Research
Concentrations:
Accepting Students
Yes
Last Updated
9/9/2016 1:08:06 PM
Research Description
Molecular mechanisms underlying age-related hearing loss
Department:
Pathology, Immunology & Laboratory Medicine
Concentrations:
Accepting Students
Yes
Last Updated
5/31/2016 12:49:45 PM
Research Description
Application of patient induced pluripotent stem (iPS) cells to clinical translational research;The role of mitochondrial ATP transporters in embryonic development, organ homeostasis and reproduction
Department:
Radiation Oncology
Concentrations:
Accepting Students
Yes
Last Updated
6/10/2016 7:52:38 AM
Research Description
Electrolyte and nutrient transport alteration in acute infectious and non infectious diarrheal conditions using electrophysiological techniques.
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
Yes
Last Updated
5/31/2016 4:37:29 PM
Research Description
The Vitriol lab uses live cell and super resolution microscopy to study the actin cytoskeleton in cell motility, neural development, and neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS).
Department:
Physiology & Functional Genomics
Concentrations:
Accepting Students
Yes
Last Updated
6/29/2016
Research Description
Development of technology for the noninvasive monitoring of gene & stem cell transfer in skeletal and cardiac muscle; bioengineering of skeletal muscle, studies the effect of gene gene transfer and correction from the level of the cell to the humans. Basic muscle physiology and pathophysiology related to the muscular dystrophies.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Last Updated
6/1/2016
Research Description
We study microsatellite repeat expansion diseases, including myotonic dystrophy. We use molecular, cellular, computational, and animal-based approaches to understand basic mechanisms that cause symptoms in this and related multi-systemic diseases, as well as identify treatments that will help patients. We also study RNA localization at a basic level, to understand why and how RNA molecules move to different places in the cell. We seek to combine high-throughput genomics approaches with single molecule imaging approaches to characterize and understand this new frontier in biology.
Department:
Molecular Genetics & Microbiology
Concentrations:
Accepting Students
Yes
Last Updated
6/3/2016 8:49:14 AM
Research Description
We are studying cancer cell signaling with expertise in signal transduction, genetic and epigenetic regulation, and animal models. Our current laboratory research is centered on two families of transcriptional co-activators, MAML and CRTC, which are essential components of Notch receptor signaling and LKB1-CRTC/CREB signaling pathways, respectively. We are investigating the molecular regulation and the roles of deregulated cell signaling in cancer generation and progression, with the goal of gaining molecular insights into cancer pathogenesis and identifying novel cancer diagnostic and therapeutic targets.
Department:
Anatomy & Cell Biology
Concentrations:
Accepting Students
Yes
Last Updated
5/24/2016 11:49:55 AM
Research Description
Mechanism of oncogenic transformation. Cooperation of oncogenes and suppressor genes in cancer development. Genetically engineered mice models for cancer. Targeted therapeutics in pancreatic and lung cancer models.

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